School of Pharmacy, Hunan University of Chinese Medicine, Changsha 410208, Hunan, China.
College of Pharmacy, Wonkwang University, Iksan 570-749, Korea.
Molecules. 2018 Jan 1;23(1):87. doi: 10.3390/molecules23010087.
The phytochemical study on the leaves of (Araliaceae) resulted in the discovery of a new lupane-triterpene compound, acangraciligenin S (), and a new lupane-triterpene glycoside, acangraciliside S (), as well as two known ones, 3α,11α-dihydroxy-lup-20(29)-en-23,28-dioic acid () and acankoreoside C (). Their chemical structures were elucidated by mass, 1D- and 2D-nuclear magnetic resonance (NMR) spectroscopy. The chemical structures of the new compounds and were determined to be 1β,3α-dihydroxy-lup-20(29)-en-23, 28-dioic acid and 1β,3α-dihydroxy-lup-20(29)-en-23,28-dioic acid 28--[α-l-rhamnopyranosyl-(1→4)-β-d-glucopyranosyl-(1→6)-β-d-glucopyranosyl] ester, respectively. The anti-neuroinflammatory activity of the selective compounds, and , were evaluated with lipopolysaccharide (LPS)-induced BV2 microglia. The tested compounds showed moderate inhibitory effect of nitric oxide (NO) production.
从（伞形科）叶的植物化学研究中发现了一种新的羽扇豆烷三萜化合物，acangraciligenin S（），和一种新的羽扇豆烷三萜糖苷，acangraciliside S（），以及两种已知的化合物，3α,11α-二羟基-羊毛甾-20(29)-烯-23,28-二酸（）和 acankoreoside C（）。它们的化学结构通过质谱、1D 和 2D 核磁共振（NMR）光谱阐明。新化合物和的化学结构被确定为 1β,3α-二羟基-羊毛甾-20(29)-烯-23,28-二酸和 1β,3α-二羟基-羊毛甾-20(29)-烯-23,28-二酸 28--[α-l-鼠李吡喃糖基-(1→4)-β-d-吡喃葡萄糖基-(1→6)-β-d-吡喃葡萄糖基]酯，分别。选择化合物、和的抗神经炎症活性用脂多糖（LPS）诱导的 BV2 小胶质细胞进行评估。测试的化合物表现出对一氧化氮（NO）产生的适度抑制作用。
