Huang Li-Ping, Zhou Rong, Meng Xiao-Fang, Yu Ri-Yue, Liu Hong-Ning, Sun Jian-Ning
Jiang Xi College of Traditional Chinese Medicine, Nangchang 330004, China.
Zhong Yao Cai. 2010 Apr;33(4):575-7.
To observe the effect on energy metabolism of rats with cold property Chinese medicine Radix Scutellariae.
The body weight gain, temperature, hydroposia content were determined before administration and every five days after administration. The activities of Na4(+)-K(+)-ATPase, Ca(2+)-ATPase and SDH, LPL, HP, the contents of NEAF, T3, T4, TSH were measured after having been administrated with water extracts of Radix Scutullaxiae at the dose of 6.0, 3.0 g/kg for 43 days.
The body weight gains were raised and the hydroposia contents have been decreased. The activities of SDH were increased significantly while Na(+)-K(+)-ATPase, Ca(2+)-ATPase of liver had little change. The content of NEAF, the activity of LPL, HP were decreased significantly, and the contents of T3, T4, TSH and the body weight, temperature had no significant change.
Radix Scutellariae can inhibit the energy metabolism of rat. The mechanism may not be related to thyroxine pathway.
观察寒性中药黄芩对大鼠能量代谢的影响。
给药前及给药后每5天测定大鼠体重增加量、体温、含水量。以6.0、3.0 g/kg黄芩水提取物灌胃43天后，测定大鼠肝组织中Na⁺-K⁺-ATP酶、Ca²⁺-ATP酶、琥珀酸脱氢酶（SDH）、脂蛋白脂肪酶（LPL）、羟脯氨酸（HP）活性及去甲肾上腺素（NEAF）、三碘甲状腺原氨酸（T3）、甲状腺素（T4）、促甲状腺激素（TSH）含量。
大鼠体重增加，含水量降低。肝组织中SDH活性显著升高，Na⁺-K⁺-ATP酶、Ca²⁺-ATP酶活性变化不明显。NEAF含量、LPL及HP活性显著降低，T3、T4、TSH含量及大鼠体重、体温变化不明显。
黄芩可抑制大鼠能量代谢，其机制可能与甲状腺素途径无关。
