Liu Shumin, Liu Changfeng, Zu Jinxiang, Li Junhang, Wang Na, Lu Fang
Institute of Traditional Chinese Medicine, Heilongjiang University of Chinese Medicine, Harbin 150040, China.
Zhongguo Zhong Yao Za Zhi. 2011 May;36(9):1212-6.
Metabonomics researches of Scutellariae Radix interfering pyretic pulmonary syndrome had been done, to determine the specific biomarkers of pyretic pulmonary syndrome, and to approach the mechanism that Scutellariae Radix interfered the variation of these biomarkers.
Metabonomics technique, UPLC-Q-TOF/MS analytical means and PCA statistical methods were utilized to investigate the trajectory change and inter-relationship of urinary metabolome of rats treated differently.
Six specific biomarkers were determined which could represent Streptococcus pneumoniae-induced pyretic pulmonary syndrome in rats. Scutellariae Radix could significantly adjust the ascended biomarkers to the normal level. Meanwhile two of these biomarkers were identified as Delta-12-prostaglandin J2 and indoxyl sulfate.
There was a good therapeutic function of Scutellariae Radix on pyretic pulmonary syndrome, which was elucidated on the metabolic aspects. There was also a correlationship between the mechanism of Scutellariae Radix curing pyretic pulmonary syndrome and the six specific biomarkers.
开展黄芩干预肺热证的代谢组学研究，确定肺热证的特异性生物标志物，并探讨黄芩干预这些生物标志物变化的机制。
运用代谢组学技术、超高效液相色谱-四极杆飞行时间串联质谱分析手段及主成分分析统计方法，研究不同处理大鼠尿液代谢组的轨迹变化及相互关系。
确定了6种可代表大鼠肺炎链球菌诱导的肺热证的特异性生物标志物。黄芩可显著将升高的生物标志物调整至正常水平。同时，其中两种生物标志物被鉴定为Δ-12-前列腺素J2和硫酸吲哚酚。
黄芩对肺热证具有良好的治疗作用，从代谢方面得以阐明。黄芩治疗肺热证的机制与这6种特异性生物标志物之间也存在相关性。
