Chemical Biology Department, Advanced Science Institute, RIKEN, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan.
Org Lett. 2010 Oct 15;12(20):4564-7. doi: 10.1021/ol1018618.
Systematic isolation of microbial metabolites has been performed to construct microbial metabolite libraries or fraction libraries. A novel macrolactam, verticilactam (1), was isolated from a library of Streptomyces spiroverticillatus JC-8444. The structure was determined on the basis of NMR and mass spectrometric measurements. 1 had a unique 16-membered macrolactam skeleton including a β-keto-amide moiety.
已经进行了微生物代谢产物的系统分离，以构建微生物代谢产物文库或馏分文库。从链霉菌属 JC-8444 的文库中分离到一种新的大环内酯verticilactam（1）。根据 NMR 和质谱测量确定了结构。1 具有独特的 16 元大环内酯骨架，包括β-酮酰胺部分。
