深海来源新大环内酯
Novel Macrolactams from a Deep-Sea-Derived Species.
机构信息
Key Laboratory of Marine Drugs, Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China.
Hainan Key Laboratory of Research and Development of Natural Product from Li Folk Medicine, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China.
出版信息
Mar Drugs. 2020 Dec 29;19(1):13. doi: 10.3390/md19010013.
Four polyene macrolactams including the previously reported niizalactam C (), and three new ones, streptolactams A-C (-) with a 26-membered monocyclic, [4,6,20]-fused tricyclic and 11,23-oxygen bridged [14,16]-bicyclic skeletons, respectively, were isolated from the fermentation broth of the deep-sea sediment-derived sp. OUCMDZ-3159. Their structures were determined based on spectroscopic analysis, X-ray diffraction analysis, and chemical methods. The abiotic formation of compounds and from compound were confirmed by a series of chemical reactions under heat and light conditions. Compounds and showed a selective antifungal activity against ATCC 10231.
从深海沉积物来源的 sp. OUCMDZ-3159 的发酵液中分离得到四个聚烯大环内酯化合物，包括先前报道的尼扎拉他姆 C ()，以及三个新化合物，链霉菌内酯 A-C (-)，分别具有 26 元单环、[4,6,20]-稠合的三环和 11,23-氧桥接的[14,16]-双环骨架。它们的结构是根据光谱分析、X 射线衍射分析和化学方法确定的。通过在热和光条件下的一系列化学反应，证实了化合物 和 是由化合物 非生物形成的。化合物 和 对 ATCC 10231 表现出选择性抗真菌活性。
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