Asculai S S, Weis M T, Rancourt M W, Kupferberg A B
Antimicrob Agents Chemother. 1978 Apr;13(4):686-90. doi: 10.1128/AAC.13.4.686.
Nonionic surface-active agents possessing ether or amide linkages between the hydrophillic and hydrophobic portions of the molecule rapidly inactivated the infectivity of herpes simplex viruses. The activity stemmed from the ability of nonionic surfactants to dissolve lipid-containing membranes. This was confirmed by observing surfactant destruction of mammalian cell plasma membranes and herpes simplex virus envelopes. Proprietary vaginal contraceptive formulations containing nonionic surfactants also inactivated herpes simplex virus infectivity. This observation suggests that nonionic surfactants in appropriate formulation could effectively prevent herpes simplex virus transmission.
在分子的亲水部分和疏水部分之间具有醚键或酰胺键的非离子表面活性剂能迅速使单纯疱疹病毒的感染性失活。这种活性源于非离子表面活性剂溶解含脂膜的能力。通过观察表面活性剂对哺乳动物细胞质膜和单纯疱疹病毒包膜的破坏得以证实。含有非离子表面活性剂的专利阴道避孕制剂也能使单纯疱疹病毒的感染性失活。这一观察结果表明，适当配方中的非离子表面活性剂可以有效预防单纯疱疹病毒的传播。
