Department of Etiology and Carcinogenesis, State Key Laboratory of Molecular Oncology, Beijing Key Laboratory for Carcinogenesis and Cancer Prevention, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Int J Immunogenet. 2011 Feb;38(1):51-4. doi: 10.1111/j.1744-313X.2010.00969.x. Epub 2010 Sep 16.
Human papilloma virus plays a causal role in cervical carcinogenesis. However, only a small portion of infected individuals develop cervical cancer. Host genetic factors may confer susceptibility to this disease. CD28 participates in the maintenance of immune homeostasis as an important positive co-stimulatory molecule. Allelic variation of immuno-modulatory genes may be associated with alteration in immune function. This study investigated the associations between CD28 IVS3 +17T>C polymorphism and risk of cervical cancer in the Chinese population. Genotypes of CD28 polymorphism were detected in 619 cases with primary cervical cancer and in 985 normal controls. The odds ratios (ORs) and 95% confidence intervals (CIs) were calculated by unconditional logistic regression. A higher frequency of CD28 +17TC heterozygote was determined in patients in comparison with controls (19.4% versus 12.5%). Subjects carrying at least one CD28 IVS3 +17 C allele (TC or CC genotype) had increased risk of cervical cancer (OR=1.66, 95% CI=1.27-2.17). This study suggests that the CD28 IVS3 +17T>C polymorphism might be genetic susceptibility factor for cervical cancer in Chinese population.
人乳头瘤病毒在宫颈癌的发生中起着因果关系。然而，只有一小部分感染个体发展为宫颈癌。宿主遗传因素可能使易感性增加。CD28 作为一个重要的正向共刺激分子，参与维持免疫稳态。免疫调节基因的等位基因变异可能与免疫功能的改变有关。本研究探讨了 CD28 IVS3+17T>C 多态性与中国人群宫颈癌易感性的关系。在 619 例原发性宫颈癌患者和 985 例正常对照中检测了 CD28 多态性的基因型。采用非条件 logistic 回归计算比值比（OR）和 95%置信区间（CI）。与对照组相比，患者中 CD28+17TC 杂合子的频率更高（19.4%对 12.5%）。携带至少一个 CD28 IVS3+17C 等位基因（TC 或 CC 基因型）的个体患宫颈癌的风险增加（OR=1.66，95%CI=1.27-2.17）。本研究提示 CD28 IVS3+17T>C 多态性可能是中国人群宫颈癌的遗传易感因素。
