Cong Jianjun, Zhang Shulong, Gao Xueren
Department of Neurosurgery, Affiliated Zhongshan Hospital of Dalian University, Dalian, Liaoning, 116001, China.
Tumour Biol. 2014 Sep;35(9):9195-200. doi: 10.1007/s13277-014-2204-6. Epub 2014 Jun 14.
Many studies have examined the association between CD28 T > C polymorphism (rs3116496) and cancer risk in various populations. However, results remained controversial. To assess this relationship more precisely, a meta-analysis was performed. A comprehensive literature search was performed using the PubMed database for relevant articles published (updated to January 1, 2014). Odds ratios (ORs) and 95 % confidence intervals (CIs) were used to assess the strength of the association. A total of nine studies were selected for this meta-analysis, including 3,878 cases and 4,424 controls. The results indicated that CD28 T > C polymorphism (rs3116496) was not associated with the risk of cancer in overall population (CC + CT vs. TT, OR = 1.17, 95 %CI = 0.94-1.47, P H = 0.00; CC vs. CT + TT, OR = 1.26, 95 %CI = 0.92-1.73, P H = 0.86; CC vs. TT, OR = 1.27, 95 %CI = 0.92-1.74, P H = 0.85; CT vs. TT, OR = 1.15, 95 %CI = 0.91-1.46, P H = 0.00; and C vs. T, OR = 1.17, 95 %CI = 0.97-1.41, P H = 0.00). In subgroup analysis according to cancer type, no significant association was found in cervical cancer or other cancer. However, in the subgroup analysis by ethnicity, the significant risk was found among Asians (CC + CT vs. TT, OR = 1.51, 95 %CI = 1.24-1.83, P H = 0.05; C vs. T, OR = 1.46, 95 %CI = 1.22-1.74, P H = 0.11), but not among Caucasians. The result of this meta-analysis suggested that CD28 T > C polymorphism (rs3116496) may have an increased risk of cancer in Asians.
许多研究探讨了CD28基因T > C多态性（rs3116496）与不同人群癌症风险之间的关联。然而，结果仍存在争议。为了更精确地评估这种关系，我们进行了一项荟萃分析。使用PubMed数据库对发表的相关文章进行了全面的文献检索（更新至2014年1月1日）。采用优势比（OR）和95%置信区间（CI）来评估关联强度。本荟萃分析共纳入9项研究，包括3878例病例和4424例对照。结果表明，CD28基因T > C多态性（rs3116496）与总体人群的癌症风险无关（CC + CT vs. TT，OR = 1.17，95%CI = 0.94 - 1.47，P H = 0.00；CC vs. CT + TT，OR = 1.26，95%CI = 0.92 - 1.73，P H = 0.86；CC vs. TT，OR = 1.27，95%CI = 0.92 - 1.74，P H = 0.85；CT vs. TT，OR = 1.15，95%CI = 0.91 - 1.46，P H = 0.00；C vs. T，OR = 1.17，95%CI = 0.97 - 1.41，P H = 0.00）。在根据癌症类型进行的亚组分析中，未发现宫颈癌或其他癌症存在显著关联。然而，在按种族进行的亚组分析中，亚洲人群存在显著风险（CC + CT vs. TT，OR = 1.51，95%CI = 1.24 - 1.83，P H = 0.05；C vs. T，OR = 1.46，95%CI = 1.22 - 1.74，P H = 0.11），而高加索人群中则未发现。该荟萃分析结果表明，CD28基因T > C多态性（rs3116496）可能会增加亚洲人群患癌风险。
