Rosato E, Pisarri S, Salsano F
J Biol Regul Homeost Agents. 2010 Jul-Sep;24(3):251-9.
Autoimmune disease therapy may be considered a puzzle under construction. Current treatments for autoimmune diseases include physical therapy, non-steroidal anti-inflammatory drugs (NSAIDs), corticosteroids, disease-modifying anti-inflammatory drugs (DMARDs), anticytokine therapies, inhibition of intracellular-signaling pathways, costimulation inhibition, biological inhibitors of T cell function, B-cell anergy and depletion, regulatory T cells, stem cell transplantion. New biologic drugs that target specific cells or cytokines involved in the early inflammatory response started because of their improved efficacy and limited toxicity. The hematopoietic stem cell transplantation represents a possible therapeutic strategy for autoimmune diseases resistant to available treatments.
自身免疫性疾病的治疗可被视为一个正在构建的谜题。目前针对自身免疫性疾病的治疗方法包括物理治疗、非甾体抗炎药（NSAIDs）、皮质类固醇、病情缓解抗风湿药（DMARDs）、抗细胞因子疗法、细胞内信号通路抑制、共刺激抑制、T细胞功能的生物抑制剂、B细胞失能和清除、调节性T细胞、干细胞移植。由于疗效提高且毒性有限，针对参与早期炎症反应的特定细胞或细胞因子的新型生物药物应运而生。造血干细胞移植是对现有治疗有抵抗性的自身免疫性疾病的一种可能的治疗策略。
