Clinical Research Development Center, Imam Reza Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Pharmaceutical Sciences Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah 6734667149, Iran.
J Immunol Res. 2021 Jun 24;2021:9920416. doi: 10.1155/2021/9920416. eCollection 2021.
Scleroderma is a complex disease involving autoimmune, vascular, and connective tissues, with unknown etiology that can progress through any organ systems.
Yet, no cure is available; the thorough treatment of scleroderma and current treatments are based on controlling inflammation. Nowadays, medicinal plants/natural-based formulations are emerging as important regulators of many diseases, including autoimmune diseases. Here, we provided an overview of scleroderma, also focused on recent studies on medicinal plants/natural-based formulations that are beneficial in scleroderma treatment/prevention.
This study is the result of a search in PubMed, Scopus, and Cochrane Library with "scleroderma", "systemic sclerosis", "plant", "herb", and "phytochemical" keywords. Finally, 22 articles were selected from a total of 1513 results entered in this study.
Natural products can modulate the inflammatory and/or oxidative mediators, regulate the production or function of the immune cells, and control the collagen synthesis, thereby attenuating the experimental and clinical manifestation of the disease.
Natural compounds can be considered an adjunct treatment for scleroderma to improve the quality of life of patients suffering from this disease.
硬皮病是一种涉及自身免疫、血管和结缔组织的复杂疾病，病因不明，可累及任何器官系统。
目前尚无治愈方法，硬皮病的彻底治疗和现有治疗方法基于控制炎症。如今，药用植物/天然配方作为许多疾病（包括自身免疫性疾病）的重要调节剂而崭露头角。在这里，我们对硬皮病进行了概述，同时还重点介绍了最近关于药用植物/天然配方在硬皮病治疗/预防方面有益的研究。
本研究是在 PubMed、Scopus 和 Cochrane Library 中使用“硬皮病”、“系统性硬化症”、“植物”、“草药”和“植物化学物质”关键词进行搜索的结果。最后，从总共输入本研究的 1513 项结果中选择了 22 篇文章。
天然产物可以调节炎症和/或氧化介质，调节免疫细胞的产生或功能，并控制胶原合成，从而减轻疾病的实验和临床表现。
天然化合物可以被认为是硬皮病的辅助治疗方法，以提高患有这种疾病的患者的生活质量。
