Riccioni G, Bucciarelli V, Scotti L, Aceto A, D Orazio N, Di Ilio E, Bucciarelli T
San Camillo de Lellis Hospital, Manfredonia, Foggia, Italy.
J Biol Regul Homeost Agents. 2010 Jul-Sep;24(3):351-8.
Asymmetric dimethylarginine (ADMA) is an endogenous inhibitor of nitric oxide (NO) associated with an increased risk of cardiovascular disease (CVD). In this study we assessed the relationship between ADMA and asymptomatic carotid intima-media thickness (CIMT). Eighty subjects underwent a complete history and physical examination, determination of serum chemistries and ADMA levels, and carotid ultrasound investigation (CUI). None of the subjects had symptoms of carotid atherosclerosis and nor were they taking any medication. Statistical analyses showed that high plasma levels of ADMA were positively correlated to CIMT (p less than 0.001). Total cholesterol, low density lipoprotein cholesterol, triglycerides and C-reactive protein plasma concentrations were significantly associated with asymptomatic carotid atherosclerosis (p less than 0.001). High serum concentrations of ADMA were associated with early carotid atherosclerotic lesions as measured by CIMT and represent a new marker of asymptomatic carotid atherosclerosis.
不对称二甲基精氨酸（ADMA）是一种内源性一氧化氮（NO）抑制剂，与心血管疾病（CVD）风险增加相关。在本研究中，我们评估了ADMA与无症状颈动脉内膜中层厚度（CIMT）之间的关系。80名受试者接受了全面的病史和体格检查、血清化学指标及ADMA水平测定，以及颈动脉超声检查（CUI）。所有受试者均无颈动脉粥样硬化症状，且未服用任何药物。统计分析表明，血浆ADMA水平升高与CIMT呈正相关（p<0.001）。总胆固醇、低密度脂蛋白胆固醇、甘油三酯和C反应蛋白血浆浓度与无症状颈动脉粥样硬化显著相关（p<0.001）。通过CIMT测量，高血清ADMA浓度与早期颈动脉粥样硬化病变相关，是无症状颈动脉粥样硬化的一个新标志物。
