Hasanoğlu Alev, Okur Ilyas, Oren Ayşe Ceyda, Biberoğlu Gürsel, Oktar Suna, Eminoğlu Fatma Tuba, Tümer Leyla
Department of Pediatric Nutrition and Metabolism, Gazi University Faculty of Medicine, Ankara, Turkey.
Turk J Pediatr. 2011 Sep-Oct;53(5):522-7.
The aim of this study was to examine the intima-media thickness (IMT) of carotid arteries and endothelial function parameters such as plasma asymmetric dimethylarginine (ADMA) and homocysteine levels in hypercholesterolemic children and to investigate the relations of these parameters with hypercholesterolemia. Fifty-seven hypercholesterolemic and 37 healthy children were included in the study. Hypercholesterolemia was defined as 155 mg/dl and above for low-density lipoprotein (LDL)-cholesterol. Plasma concentrations of ADMA and homocysteine were measured and the measurement of carotid IMT was determined. Both carotid IMT and plasma ADMA levels were significantly higher in hypercholesterolemic children than healthy children (p<0.01). No significant difference was determined in homocysteine concentration between hypercholesterolemic children and the control group (p>0.05). No significant correlation was observed between lipid profiles and the levels of ADMA and homocysteine. However, a significant positive correlation was found between carotid IMT and total and LDL-cholesterol levels and between the levels of ADMA and LDL-cholesterol. In conclusion, the progressive increase in ADMA levels and carotid IMT and the positive relationship between carotid IMT and serum cholesterol levels support that plasma ADMA levels and carotid IMT can be indicators of early atherosclerosis in hypercholesterolemic children.
本研究旨在检测高胆固醇血症患儿颈动脉内膜中层厚度（IMT）以及内皮功能参数，如血浆不对称二甲基精氨酸（ADMA）和同型半胱氨酸水平，并探究这些参数与高胆固醇血症的关系。57名高胆固醇血症患儿和37名健康儿童纳入本研究。高胆固醇血症定义为低密度脂蛋白（LDL）胆固醇水平在155mg/dl及以上。测定血浆ADMA和同型半胱氨酸浓度，并检测颈动脉IMT。高胆固醇血症患儿的颈动脉IMT和血浆ADMA水平均显著高于健康儿童（p<0.01）。高胆固醇血症患儿与对照组之间的同型半胱氨酸浓度无显著差异（p>0.05）。血脂谱与ADMA和同型半胱氨酸水平之间未观察到显著相关性。然而，颈动脉IMT与总胆固醇和LDL胆固醇水平之间以及ADMA水平与LDL胆固醇之间存在显著正相关。总之，ADMA水平和颈动脉IMT的逐渐升高以及颈动脉IMT与血清胆固醇水平之间的正相关支持血浆ADMA水平和颈动脉IMT可作为高胆固醇血症患儿早期动脉粥样硬化的指标。
