利用激光共聚焦扫描显微镜评估眼部蠕形螨病。
In vivo evaluation of ocular demodicosis using laser scanning confocal microscopy.
机构信息
Johnson & Johnson Department of Ocular Surface and Visual Optics, Keio University School of Medicine, Tokyo, Japan.
出版信息
Invest Ophthalmol Vis Sci. 2011 Feb 1;52(1):565-9. doi: 10.1167/iovs.10-5477.
PURPOSE
To investigate the applicability of in vivo laser scanning confocal microscopy in the diagnosis and follow-up of ocular demodicosis infestation in a prospective controlled study.
METHODS
Fifteen right eyes of 15 patients with blepharitis associated with cylindrical dandruff (10 males, 5 females; mean age: 62.9 ± 9 years) and eight right eyes of eight age- and sex-matched control subjects underwent HRTII/RCM, evaluation of ocular symptom scores, tear function tests including vital stainings, Schirmer test, and tear clearance test, and evaluation of mite numbers in the eyelids.
RESULTS
In vivo confocal microscopy effectively disclosed the mites in the terminal bulbs of the eyelashes, which were not observed after treatment. Eyelids with demodicosis infestation showed marked inflammatory infiltrates around the meibomian glands and conjunctiva, which cleared with tea tree oil treatment.
CONCLUSIONS
Laser scanning confocal microscopy seems to be an efficient noninvasive tool in the diagnosis and follow-up of ocular demodicosis infestation.
目的
在一项前瞻性对照研究中，通过活体激光扫描共聚焦显微镜（in vivo laser scanning confocal microscopy）来诊断和随访眼部蠕形螨病感染，以探究其适用性。
方法
15 例（10 男，5 女；平均年龄：62.9 ± 9 岁）伴有圆柱状头皮屑的睑缘炎患者的 15 只右眼和 8 例年龄、性别匹配的对照组患者的 8 只右眼，均接受 HRTII/RCM、眼表症状评分评估、泪液功能检查（包括 vital staining、Schirmer 试验和泪液清除试验）以及评估眼睑内的螨虫数量。
结果
活体共聚焦显微镜可有效显示螨虫在睫毛的终末毛囊中，治疗后则无法观察到。蠕形螨病感染的眼睑有明显的睑板腺和结膜周围炎症浸润，经茶树油治疗后可清除。
结论
激光扫描共聚焦显微镜似乎是一种有效的、非侵入性的眼部蠕形螨病诊断和随访工具。
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