t(X;14)(p22;q32)/t(Y;14)(p11;q32) CRLF2-IGH translocations from human B-lineage ALLs involve CpG-type breaks at CRLF2, but CRLF2/P2RY8 intrachromosomal deletions do not.
作者信息
Tsai Albert G, Yoda Akinori, Weinstock David M, Lieber Michael R
出版信息
Blood. 2010 Sep 16;116(11):1993-4. doi: 10.1182/blood-2010-05-286492.
Abstract
摘要
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t(X;14)(p22;q32)/t(Y;14)(p11;q32) CRLF2-IGH translocations from human B-lineage ALLs involve CpG-type breaks at CRLF2, but CRLF2/P2RY8 intrachromosomal deletions do not.来自人类B系急性淋巴细胞白血病的t(X;14)(p22;q32)/t(Y;14)(p11;q32) CRLF2-IGH易位涉及CRLF2处的CpG型断裂，但CRLF2/P2RY8染色体内缺失则不然。
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Functional screening identifies CRLF2 in precursor B-cell acute lymphoblastic leukemia.功能筛选鉴定出前 B 细胞急性淋巴细胞白血病中的 CRLF2。
Proc Natl Acad Sci U S A. 2010 Jan 5;107(1):252-7. doi: 10.1073/pnas.0911726107. Epub 2009 Dec 15.
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Down syndrome acute lymphoblastic leukemia, a highly heterogeneous disease in which aberrant expression of CRLF2 is associated with mutated JAK2: a report from the International BFM Study Group.唐氏综合征急性淋巴细胞白血病，一种高度异质性疾病，其中 CRLF2 的异常表达与突变型 JAK2 相关：来自国际 BFM 研究组的报告。
Blood. 2010 Feb 4;115(5):1006-17. doi: 10.1182/blood-2009-08-235408. Epub 2009 Nov 24.
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Rearrangement of CRLF2 in B-progenitor- and Down syndrome-associated acute lymphoblastic leukemia.CRLF2在B祖细胞和唐氏综合征相关急性淋巴细胞白血病中的重排。
Nat Genet. 2009 Nov;41(11):1243-6. doi: 10.1038/ng.469. Epub 2009 Oct 18.
5
Deregulated expression of cytokine receptor gene, CRLF2, is involved in lymphoid transformation in B-cell precursor acute lymphoblastic leukemia.细胞因子受体基因CRLF2的表达失调与B细胞前体急性淋巴细胞白血病的淋巴细胞转化有关。
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Human chromosomal translocations at CpG sites and a theoretical basis for their lineage and stage specificity.人类染色体在CpG位点的易位及其谱系和阶段特异性的理论基础。
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