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1
The t(14;18)(q32;q21)/IGH-MALT1 translocation in MALT lymphomas is a CpG-type translocation, but the t(11;18)(q21;q21)/API2-MALT1 translocation in MALT lymphomas is not.黏膜相关淋巴组织淋巴瘤中的t(14;18)(q32;q21)/IGH-MALT1易位是一种CpG型易位,但黏膜相关淋巴组织淋巴瘤中的t(11;18)(q21;q21)/API2-MALT1易位则不是。
Blood. 2010 Apr 29;115(17):3640-1; author reply 3641-2. doi: 10.1182/blood-2010-01-265157.
2
The t(14;18)(q32;q21)/IGH-MALT1 translocation in MALT lymphomas contains templated nucleotide insertions and a major breakpoint region similar to follicular and mantle cell lymphoma.MALT 淋巴瘤中的 t(14;18)(q32;q21)/IGH-MALT1 易位含有模板核苷酸插入和类似于滤泡性和套细胞淋巴瘤的主要断裂点区域。
Blood. 2010 Mar 18;115(11):2214-9. doi: 10.1182/blood-2009-08-236265. Epub 2009 Nov 25.
3
T(14;18)(q32;q21) involving IGH and MALT1 is a frequent chromosomal aberration in MALT lymphoma.涉及IGH和MALT1的T(14;18)(q32;q21)是黏膜相关淋巴组织淋巴瘤中常见的染色体畸变。
Blood. 2003 Mar 15;101(6):2335-9. doi: 10.1182/blood-2002-09-2963. Epub 2002 Oct 24.
4
[Study on genetic aberrations of ocular mucosa-associated lymphoid tissue lymphomas occurring in southern China].[中国南方眼部黏膜相关淋巴组织淋巴瘤的基因畸变研究]
Zhonghua Bing Li Xue Za Zhi. 2010 Aug;39(8):513-7.
5
MALT lymphoma with t(14;18)(q32;q21)/IGH-MALT1 is characterized by strong cytoplasmic MALT1 and BCL10 expression.伴有t(14;18)(q32;q21)/IGH-MALT1的黏膜相关淋巴组织淋巴瘤的特征是细胞质MALT1和BCL10呈强表达。
J Pathol. 2005 Feb;205(3):293-301. doi: 10.1002/path.1715.
6
The t(14;18)(q32;q21)/IGH-MALT1 translocation in gastrointestinal extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma).胃肠道黏膜相关淋巴组织边缘区淋巴瘤(MALT淋巴瘤)中的t(14;18)(q32;q21)/IGH-MALT1易位
Histopathology. 2014 May;64(6):791-8. doi: 10.1111/his.12327. Epub 2014 Jan 10.
7
t(14;18)(q32;q21) involving IGH and MALT1 is uncommon in cutaneous MALT lymphomas and primary cutaneous diffuse large B-cell lymphomas.涉及IGH和MALT1的t(14;18)(q32;q21)在皮肤黏膜相关淋巴组织淋巴瘤和原发性皮肤弥漫性大B细胞淋巴瘤中并不常见。
J Cutan Pathol. 2006 Apr;33(4):286-92. doi: 10.1111/j.0303-6987.2006.00459.x.
8
T(14;18)(q32;q21) involving MALT1 and IGH genes in an extranodal diffuse large B-cell lymphoma.14号和18号染色体发生(14;18)(q32;q21)易位,累及结外弥漫性大B细胞淋巴瘤中的MALT1和IGH基因。
Hum Pathol. 2003 Nov;34(11):1212-5. doi: 10.1016/j.humpath.2003.08.007.
9
Primary cutaneous marginal zone B-cell lymphoma may exhibit both the t(14;18)(q32;q21) IGH/BCL2 and the t(14;18)(q32;q21) IGH/MALT1 translocation: an indicator for clonal transformation towards higher-grade B-cell lymphoma?原发性皮肤边缘区B细胞淋巴瘤可能同时出现t(14;18)(q32;q21)IGH/BCL2和t(14;18)(q32;q21)IGH/MALT1易位:这是向高级别B细胞淋巴瘤克隆转化的一个指标吗?
Am J Dermatopathol. 2007 Jun;29(3):231-6. doi: 10.1097/DAD.0b013e31804795a6.
10
The translocations t(6;18;11)(q24;q21;q21) and t(11;14;18)(q21;q32;q21) lead to a fusion of the API2 and MALT1 genes and occur in MALT lymphomas.易位t(6;18;11)(q24;q21;q21)和t(11;14;18)(q21;q32;q21)导致API2和MALT1基因融合,发生于黏膜相关淋巴组织淋巴瘤(MALT淋巴瘤)。
Haematologica. 2007 Mar;92(3):405-9. doi: 10.3324/haematol.10268.

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1
Increased AID results in mutations at the CRLF2 locus implicated in Latin American ALL health disparities.AID 水平的升高导致 CRLF2 基因座发生突变,这与拉丁美洲 ALL 之间的健康差异有关。
Nat Commun. 2024 Jul 27;15(1):6331. doi: 10.1038/s41467-024-50537-0.
2
The RNA tether model for human chromosomal translocation fragile zones.人类染色体易位脆性区的 RNA 系绳模型。
Trends Biochem Sci. 2024 May;49(5):391-400. doi: 10.1016/j.tibs.2024.02.003. Epub 2024 Mar 14.
3
Nonamer dependent RAG cleavage at CpGs can explain mechanism of chromosomal translocations associated to lymphoid cancers.非九聚体依赖的 RAG 在 CpG 上的切割可以解释与淋巴细胞癌相关的染色体易位的机制。
PLoS Genet. 2022 Oct 13;18(10):e1010421. doi: 10.1371/journal.pgen.1010421. eCollection 2022 Oct.
4
The mechanisms of human lymphoid chromosomal translocations and their medical relevance.人类淋巴染色体易位的机制及其医学相关性。
Crit Rev Biochem Mol Biol. 2022 Jun;57(3):227-243. doi: 10.1080/10409238.2021.2004576. Epub 2021 Dec 7.
5
Mechanistic basis for chromosomal translocations at the E2A gene and its broader relevance to human B cell malignancies.E2A基因染色体易位的机制基础及其与人类B细胞恶性肿瘤的更广泛相关性。
Cell Rep. 2021 Jul 13;36(2):109387. doi: 10.1016/j.celrep.2021.109387.
6
Burkitt leukemia with precursor B-cell features that developed after ruxolitinib treatment in a patient with hydroxyurea-refractory JAK2-myeloproliferative neoplasm.患者因 JAK2 骨髓增殖性肿瘤对羟基脲耐药而接受芦可替尼治疗后,出现具有前 B 细胞特征的伯基特白血病。
J Clin Exp Hematop. 2021 Jun 5;61(2):114-119. doi: 10.3960/jslrt.21001. Epub 2021 May 14.
7
Pulmonary extranodal marginal zone lymphoma that presented with macroglobulinemia and marked plasmacytic cell proliferation carrying the t(14;18)(q32;q21)/MALT1-immunoglobulin heavy-chain fusion gene in pleural fluid.伴有巨球蛋白血症及显著浆细胞增殖的肺结外边缘区淋巴瘤,其胸腔积液中携带t(14;18)(q32;q21)/MALT1-免疫球蛋白重链融合基因
J Clin Exp Hematop. 2018 Sep 19;58(3):141-147. doi: 10.3960/jslrt.18013. Epub 2018 Aug 8.
8
Mechanisms of human lymphoid chromosomal translocations.人类淋巴样染色体易位的机制。
Nat Rev Cancer. 2016 May 25;16(6):387-98. doi: 10.1038/nrc.2016.40.
9
Radical surgery may be not an optimal treatment approach for pulmonary MALT lymphoma.根治性手术可能并非肺黏膜相关淋巴组织淋巴瘤的最佳治疗方法。
Tumour Biol. 2015 Aug;36(8):6409-16. doi: 10.1007/s13277-015-3329-y. Epub 2015 Mar 24.
10
Human lymphoid translocation fragile zones are hypomethylated and have accessible chromatin.人类淋巴易位脆性区域存在低甲基化且具有可及染色质。
Mol Cell Biol. 2015 Apr;35(7):1209-22. doi: 10.1128/MCB.01085-14. Epub 2015 Jan 26.

本文引用的文献

1
The t(14;18)(q32;q21)/IGH-MALT1 translocation in MALT lymphomas contains templated nucleotide insertions and a major breakpoint region similar to follicular and mantle cell lymphoma.MALT 淋巴瘤中的 t(14;18)(q32;q21)/IGH-MALT1 易位含有模板核苷酸插入和类似于滤泡性和套细胞淋巴瘤的主要断裂点区域。
Blood. 2010 Mar 18;115(11):2214-9. doi: 10.1182/blood-2009-08-236265. Epub 2009 Nov 25.
2
Human chromosomal translocations at CpG sites and a theoretical basis for their lineage and stage specificity.人类染色体在CpG位点的易位及其谱系和阶段特异性的理论基础。
Cell. 2008 Dec 12;135(6):1130-42. doi: 10.1016/j.cell.2008.10.035.
3
t(11;18)(q21;q21) of mucosa-associated lymphoid tissue lymphoma results from illegitimate non-homologous end joining following double strand breaks.黏膜相关淋巴组织淋巴瘤的t(11;18)(q21;q21)是由双链断裂后异常的非同源末端连接导致的。
Br J Haematol. 2004 May;125(3):318-29. doi: 10.1111/j.1365-2141.2004.04909.x.
4
Molecular characterization of the genomic breakpoint junction in the t(11;18) (q21;q21) translocation of a gastric MALT lymphoma.
Biochem Biophys Res Commun. 2001 Jan 12;280(1):301-6. doi: 10.1006/bbrc.2000.4124.
5
The product of the t(11;18), an API2-MLT fusion, marks nearly half of gastric MALT type lymphomas without large cell proliferation.t(11;18)的产物,即API2-MLT融合基因,在无大细胞增殖的胃黏膜相关淋巴组织型淋巴瘤中占近一半。
Am J Pathol. 2000 Apr;156(4):1433-9. doi: 10.1016/S0002-9440(10)65012-2.

The t(14;18)(q32;q21)/IGH-MALT1 translocation in MALT lymphomas is a CpG-type translocation, but the t(11;18)(q21;q21)/API2-MALT1 translocation in MALT lymphomas is not.

作者信息

Tsai Albert G, Lu Zhengfei, Lieber Michael R

出版信息

Blood. 2010 Apr 29;115(17):3640-1; author reply 3641-2. doi: 10.1182/blood-2010-01-265157.

DOI:10.1182/blood-2010-01-265157
PMID:20430965
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2867271/
Abstract
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