白细胞介素-9 的细胞来源和免疫功能。
Cellular sources and immune functions of interleukin-9.
机构信息
Department of Microbiology and Immunology, Dartmouth Medical School, Lebanon, New Hampshire 03756, USA.
出版信息
Nat Rev Immunol. 2010 Oct;10(10):683-7. doi: 10.1038/nri2848. Epub 2010 Sep 17.
Abstract
Interleukin-9 (IL-9) has attracted renewed interest owing to the identification of its expression by multiple T helper (T(H)) cell subsets, including T(H)2 cells, T(H)9 cells, T(H)17 cells and regulatory T (T(Reg)) cells. Here, we provide a broad overview of the conditions that are required for cells to produce IL-9 and describe the cellular targets and nature of the immune responses that are induced by IL-9.
摘要
白细胞介素-9（IL-9）因其在多种辅助性 T 细胞（T(H)）亚群中的表达而受到重新关注，包括 T(H)2 细胞、T(H)9 细胞、T(H)17 细胞和调节性 T（T(Reg)）细胞。在此，我们提供了细胞产生 IL-9 所需条件的广泛概述，并描述了 IL-9 诱导的细胞靶标和免疫反应的性质。
相似文献
1
Cellular sources and immune functions of interleukin-9.
Nat Rev Immunol. 2010 Oct;10(10):683-7. doi: 10.1038/nri2848. Epub 2010 Sep 17.
2
TH9 cell generation. TH9: the latest addition to the expanding repertoire of IL-25 targets.
Immunol Cell Biol. 2010 Jul;88(5):502-4. doi: 10.1038/icb.2010.43. Epub 2010 Mar 23.
3
TH9 cells are required for tissue mast cell accumulation during allergic inflammation.
J Allergy Clin Immunol. 2015 Aug;136(2):433-40.e1. doi: 10.1016/j.jaci.2015.01.021. Epub 2015 Mar 5.
4
Th9 and other IL-9-producing cells in allergic asthma.
Semin Immunopathol. 2017 Jan;39(1):55-68. doi: 10.1007/s00281-016-0601-1. Epub 2016 Nov 17.
5
IL-9 and Th9 cells: progress and challenges.
Int Immunol. 2013 Oct;25(10):547-51. doi: 10.1093/intimm/dxt039. Epub 2013 Sep 11.
6
Interleukin-9 and T helper type 9 cells in rheumatic diseases.
Clin Exp Immunol. 2016 Aug;185(2):125-32. doi: 10.1111/cei.12807.
7
Foxp3⁺ regulatory T cells delay expulsion of intestinal nematodes by suppression of IL-9-driven mast cell activation in BALB/c but not in C57BL/6 mice.
PLoS Pathog. 2014 Feb 6;10(2):e1003913. doi: 10.1371/journal.ppat.1003913. eCollection 2014 Feb.
8
Innate IL-17-producing cells: the sentinels of the immune system.
Nat Rev Immunol. 2010 Jul;10(7):479-89. doi: 10.1038/nri2800. Epub 2010 Jun 18.
9
Th9 Cells: Probable players in ulcerative colitis pathogenesis.
Int Rev Immunol. 2018;37(4):192-205. doi: 10.1080/08830185.2018.1457659. Epub 2018 Apr 19.
10
Characterization of the anti-tumor immune response in human cancers and strategies for immunotherapy.
Crit Rev Oncol Hematol. 1994 Jun;16(3):157-79. doi: 10.1016/1040-8428(94)90069-8.
引用本文的文献
1
Loss of YTHDF2 enhances Th9 programming and CAR-Th9 cell antitumor efficacy.
Nat Immunol. 2025 Aug 18. doi: 10.1038/s41590-025-02235-2.
2
Update on Acute Tubulointerstitial Nephritis: Clinical Features, Immunologic Insights, and Diagnostic and Treatment Approaches.
Kidney Int Rep. 2025 Apr 1;10(6):1643-1656. doi: 10.1016/j.ekir.2025.03.050. eCollection 2025 Jun.
3
Systematic Druggable-Proteome-Wide Mendelian Randomization Identifies Potential Therapeutic Targets for Allergic Conjunctivitis.
Transl Vis Sci Technol. 2025 Jul 1;14(7):6. doi: 10.1167/tvst.14.7.6.
4
Predicting biomarkers of progressive pulmonary fibrosis: morphological, cytokine profile, and clinical portrait.
Front Immunol. 2025 Jun 19;16:1514439. doi: 10.3389/fimmu.2025.1514439. eCollection 2025.
5
Neuroinflammation and Amyotrophic Lateral Sclerosis: Recent Advances in Anti-Inflammatory Cytokines as Therapeutic Strategies.
Int J Mol Sci. 2025 Apr 18;26(8):3854. doi: 10.3390/ijms26083854.
6
IL-9 and Blimp-1 protects the transcriptional identity of group 2 innate lymphocytes in allergic asthma.
Res Sq. 2025 Apr 11:rs.3.rs-6365283. doi: 10.21203/rs.3.rs-6365283/v1.
7
Generation and Characterization of Human iPSC-Derived Astrocytes with Potential for Modeling X-Linked Adrenoleukodystrophy Phenotypes.
Int J Mol Sci. 2025 Feb 13;26(4):1576. doi: 10.3390/ijms26041576.
8
Targeted delivery of TGF-β mRNA to murine lung parenchyma using one-component ionizable amphiphilic Janus Dendrimers.
Nat Commun. 2025 Feb 21;16(1):1806. doi: 10.1038/s41467-025-56448-y.
9
Developing an Effective Therapeutic HPV Vaccine to Eradicate Large Tumors by Genetically Fusing Xcl1 and Incorporating IL-9 as Molecular Adjuvants.
Vaccines (Basel). 2025 Jan 9;13(1):49. doi: 10.3390/vaccines13010049.
10
Type 2 biomarkers in olfactory cleft mucus correlate with SNOT-22 in chronic rhinosinusitis independent of nasal polyp status.
Int Forum Allergy Rhinol. 2025 Apr;15(4):411-419. doi: 10.1002/alr.23503. Epub 2024 Dec 30.
本文引用的文献
1
Neutralization of IL-9 ameliorates experimental autoimmune encephalomyelitis by decreasing the effector T cell population.
J Immunol. 2010 Oct 1;185(7):4095-100. doi: 10.4049/jimmunol.1000986. Epub 2010 Aug 30.
2
Interferon-regulatory factor 4 is essential for the developmental program of T helper 9 cells.
Immunity. 2010 Aug 27;33(2):192-202. doi: 10.1016/j.immuni.2010.07.014. Epub 2010 Jul 30.
3
Oral tolerance reduces Th17 cells as well as the overall inflammation in the central nervous system of EAE mice.
J Neuroimmunol. 2010 Oct 8;227(1-2):10-7. doi: 10.1016/j.jneuroim.2010.06.002. Epub 2010 Jul 2.
4
TGF-beta induces IL-9 production from human Th17 cells.
J Immunol. 2010 Jul 1;185(1):46-54. doi: 10.4049/jimmunol.1000356. Epub 2010 May 24.
5
The transcription factor PU.1 is required for the development of IL-9-producing T cells and allergic inflammation.
Nat Immunol. 2010 Jun;11(6):527-34. doi: 10.1038/ni.1867. Epub 2010 May 2.
6
Regulation of human Th9 differentiation by type I interferons and IL-21.
Immunol Cell Biol. 2010 Aug;88(6):624-31. doi: 10.1038/icb.2010.53. Epub 2010 Apr 27.
7
Differential roles for the IL-9/IL-9 receptor alpha-chain pathway in systemic and oral antigen-induced anaphylaxis.
J Allergy Clin Immunol. 2010 Feb;125(2):469-476.e2. doi: 10.1016/j.jaci.2009.09.054.
8
Regulation of IL-9 expression by IL-25 signaling.
Nat Immunol. 2010 Mar;11(3):250-6. doi: 10.1038/ni.1846. Epub 2010 Feb 14.
9
Human CD4 memory T cells can become CD4+IL-9+ T cells.
PLoS One. 2010 Jan 14;5(1):e8706. doi: 10.1371/journal.pone.0008706.
10
Th1, Th17, and Th9 effector cells induce experimental autoimmune encephalomyelitis with different pathological phenotypes.
J Immunol. 2009 Dec 1;183(11):7169-77. doi: 10.4049/jimmunol.0901906. Epub 2009 Nov 4.
Zotero 插件