Westheim A, Os I, Kjeldsen S E, Fønstelien E, Eide I K
Department of Internal Medicine, Oslo University Medical School, Ullevaal Hospital, Norway.
Scand J Clin Lab Invest. 1990 Dec;50(8):815-22. doi: 10.3109/00365519009104947.
Nine mild-to-moderate hypertensive patients (HT), aged 41 +/- 0.6 years (mean +/- SEM) and nine age-matched normotensive control subjects (NT) were tilted to 60 degrees for 10 min. During tilt, both systolic (S) blood pressure (BP) (p less than 0.01) and diastolic (D) BP (p less than 0.05) increased in HT, but not in NT. At supine rest renal blood flow was higher in HT than in NT and increased by 17% in HT during tilt, while a decrease of 13% was observed in NT (p less than 0.05). Renal vascular resistance was unchanged in HT during tilt, while a significant increase (p less than 0.01) was observed in NT. Arterial plasma noradrenaline increased in both groups (p less than 0.05) during tilt, significantly more in HT than in NT (p less than 0.05). No statistically significant difference was observed between the groups in renal catecholamine uptake or release. Our data indicate enhanced general sympathetic and circulatory responses to tilt in subjects with mild-to-moderate essential hypertension. However, the enhanced haemodynamic and sympathetic responses were not shared by hypertensive kidneys and renovascular resistance remained unaffected by tilt.
9名轻度至中度高血压患者（HT），年龄41±0.6岁（均值±标准误），以及9名年龄匹配的血压正常对照受试者（NT）被倾斜至60度，持续10分钟。倾斜过程中，HT组的收缩压（S）（p<0.01）和舒张压（D）（p<0.05）均升高，而NT组则未升高。仰卧休息时，HT组的肾血流量高于NT组，且HT组在倾斜过程中肾血流量增加了17%，而NT组则减少了13%（p<0.05）。HT组在倾斜过程中肾血管阻力未改变，而NT组则显著增加（p<0.01）。倾斜过程中两组的动脉血浆去甲肾上腺素均增加（p<0.05），HT组增加幅度显著大于NT组（p<0.05）。两组在肾儿茶酚胺摄取或释放方面未观察到统计学显著差异。我们的数据表明，轻度至中度原发性高血压患者对倾斜的全身交感神经和循环反应增强。然而，高血压肾脏并未出现增强的血流动力学和交感神经反应，肾血管阻力也不受倾斜影响。
