Department of Neurology, NYU School of Medicine, Multiple Sclerosis Care Center, 301 East 17th Street, New York, NY 10003, USA.
Curr Pain Headache Rep. 2010 Dec;14(6):441-8. doi: 10.1007/s11916-010-0143-5.
We review the evidence for a link between multiple sclerosis (MS) and two of the most common primary headache disorders: tension-type headache and migraine. We argue that the association between migraine and MS is biologically plausible and is confirmed by most studies. We discuss possible explanations for the association. First, we consider the possibility that the association is spurious. Next, we consider unidirectional causal models in which one of the conditions increases the risk of the other. A bidirectional model would suggest that each disease predisposes to the other. Alternatively, genetic or environmental risk factors shared by each condition may account for the association between them. We also address the question of whether coexisting migraine or tension-type headache in a patient with MS affects the symptom profile, clinical course, and radiographic characteristics of MS.
我们回顾了多发性硬化症（MS）与两种最常见的原发性头痛疾病：紧张型头痛和偏头痛之间关联的证据。我们认为偏头痛和 MS 之间的关联在生物学上是合理的，并且大多数研究都证实了这一点。我们讨论了这种关联的可能解释。首先，我们考虑了这种关联是虚假的可能性。接下来，我们考虑了单向因果模型，其中一种情况会增加另一种情况的风险。双向模型则表明，每种疾病都会使另一种疾病更容易发生。或者，每种疾病共有的遗传或环境风险因素可能解释了它们之间的关联。我们还探讨了 MS 患者同时存在偏头痛或紧张型头痛是否会影响 MS 的症状谱、临床病程和影像学特征。
