Department of Nuclear Medicine and PET Center, China Medical University Hospital, Taichung, Taiwan.
Head Neck. 2010 Dec;32(12):1648-54. doi: 10.1002/hed.21377.
This study aimed to determine whether Tl-201 single photon emission CT (SPECT) is potentially useful in differentiating false-positive fluorodeoxyglucose positron emission tomography (FDG-PET) findings caused by osteoradionecrosis (ORN) from recurrent head and neck cancer after radiotherapy.
Five patients were recruited. Dual-phase FDG-PET and dual-phase Tl-201 SPECT were performed for each patient.
All 5 patients proved to have ORN without recurrent cancer. By visual interpretation, the results were 4 positive versus 1 negative for PET, and 4 negative versus 1 positive for Tl-201 SPECT. The Tl-201 SPECT clarified 3 of the 4 false-positive PETs to be ORN. Dual-phase semiquantitative studies showed decreased standardized uptake value (SUV) over time in 3 of the 4 false-positive PETs and decreased lesion/background ratio over time in the false-positive Tl-201 SPECT.
The Tl-201 SPECT may help clarify suspected false-positive FDG uptake caused by ORN. Dual-phase FDG-PET and dual-phase Tl-201 SPECT may also have some value.
本研究旨在确定 Tl-201 单光子发射 CT（SPECT）是否可用于区分放射性骨坏死（ORN）引起的氟脱氧葡萄糖正电子发射断层扫描（FDG-PET）假阳性与放疗后头颈部复发性癌症。
招募了 5 名患者。每位患者均进行了 FDG-PET 双时相和 Tl-201 SPECT 双时相检查。
5 名患者均证实患有 ORN 而无复发性癌症。通过视觉解读，结果为 PET 阳性 4 例，阴性 1 例，Tl-201 SPECT 阳性 4 例，阴性 1 例。Tl-201 SPECT 明确了 4 例假阳性 PET 中的 3 例为 ORN。双时相半定量研究显示，4 例假阳性 PET 中的 3 例标准化摄取值（SUV）随时间逐渐降低，假阳性 Tl-201 SPECT 的病变/背景比值随时间逐渐降低。
Tl-201 SPECT 可能有助于阐明 ORN 引起的疑似 FDG 摄取假阳性。FDG-PET 双时相和 Tl-201 SPECT 双时相也可能具有一定价值。
