Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada.
Head Neck. 2011 Jan;33(1):125-30. doi: 10.1002/hed.21410.
Venous malformations (VMs) are common vascular anomalies; 40% are found in the head and neck. Percutaneous sclerotherapy is 1 treatment of choice.
In all, 17 patients with facial VMs were treated by percutaneous sclerotherapy using alcohol and individually matched to lesions treated with bleomycin. Treatment details and outcomes were compared. The average numbers of sessions were 1.7 for alcohol and 3.4 for bleomycin. Average dose administered was 8.1 cm³ alcohol and 9.1 units bleomycin.
Of those treated with alcohol, 2 developed adverse effects and 7 developed complications. None treated with bleomycin developed adverse effects or complications. All patients treated with alcohol improved clinically. In all, 15 patients treated with bleomycin improved after treatment and 2 were unchanged.
Alcohol has a slightly higher success rate and requires fewer treatment sessions. Bleomycin has a lower complication rate and less postprocedural swelling. Bleomycin treatment may be better tolerated and is thus preferred over alcohol sclerotherapy.
静脉畸形（VMs）是常见的血管畸形；40%发生在头颈部。经皮硬化疗法是首选的治疗方法之一。
共对 17 例面部 VM 患者进行了经皮硬化治疗，使用酒精治疗，并与接受平阳霉素治疗的病变进行了匹配。比较了治疗细节和结果。酒精治疗的平均疗程为 1.7 次，平阳霉素为 3.4 次。酒精的平均剂量为 8.1cm³，平阳霉素为 9.1 单位。
接受酒精治疗的 2 例出现不良反应，7 例出现并发症。接受平阳霉素治疗的患者均无不良反应或并发症。所有接受酒精治疗的患者临床症状均有改善。共 15 例接受平阳霉素治疗的患者治疗后病情改善，2 例病情无变化。
酒精的成功率略高，所需疗程较少。平阳霉素的并发症发生率较低，术后肿胀程度较轻。平阳霉素治疗的耐受性可能更好，因此优于酒精硬化疗法。
