Sparks Teresa N, Cheng Yvonne W, McLaughlin Blake, Esakoff Tania F, Caughey Aaron B
Department of Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco, California, USA.
J Matern Fetal Neonatal Med. 2011 May;24(5):708-12. doi: 10.3109/14767058.2010.516285. Epub 2010 Sep 17.
To determine the utility of fundal height in screening for small-for-gestational-age (SGA) and large-for-gestational-age (LGA) neonates at term.
This was a retrospective cohort study of 3627 women at University of California, San Francisco from 2002 to 2006 with term, singleton pregnancies specifically examining the 448 who had third trimester ultrasounds for size unequal to dates by fundal height. χ(2) analyses determined the sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of fundal height as a screening tool for abnormal intrauterine growth.
The sensitivity of fundal height was 16.6% for detecting actual birthweight (BWt) > 90th percentile (p < 0.001) and 17.3% for < 10 th percentile (p < 0.001). Specificity ranged from 92.4 to 95.4%. Significant differences existed among subgroups by maternal weight, parity, age, and ethnicity. Sensitivity was lower for SGA among overweight/obese women but higher among multiparous women. Additionally, women ≥ 35 years showed higher sensitivity for extreme LGA, and several notable differences were found by ethnicity such as higher sensitivity for extreme LGA among Caucasian women.
The sensitivity of fundal height for detecting abnormal intrauterine growth was less than 35% for all subgroups, although specificity was more ideal at >90%. Other modalities should be considered to screen for growth abnormalities.
确定孕晚期宫高在筛查足月小样儿(SGA)和大于胎龄儿(LGA)中的作用。
这是一项对2002年至2006年在加利福尼亚大学旧金山分校的3627名单胎足月妊娠女性进行的回顾性队列研究,特别检查了448名因宫高与孕周不符而在孕晚期接受超声检查的女性。χ²分析确定了宫高作为筛查宫内生长异常工具的敏感性、特异性、阳性预测值(PPV)和阴性预测值(NPV)。
宫高检测实际出生体重(BWt)>第90百分位数的敏感性为16.6%(p<0.001),检测<第10百分位数的敏感性为17.3%(p<0.001)。特异性范围为92.4%至95.4%。按母亲体重、产次、年龄和种族划分的亚组之间存在显著差异。超重/肥胖女性中SGA的敏感性较低,但经产妇中较高。此外,35岁及以上女性对极端LGA的敏感性较高,按种族发现了一些显著差异,如白人女性中极端LGA的敏感性较高。
尽管特异性大于90%较为理想,但宫高检测宫内生长异常的敏感性在所有亚组中均低于35%。应考虑采用其他方法筛查生长异常。