[Pathogenetic therapy of tissue hypoxia, hemorheologic disorders and microangiopathies in patients with diabetes mellitus].

To reveal oxygen transport and hemorheological changes in derangements of carbohydrate metabolism, a unified scheme for patients' examination was devised. It includes examination of oxygen metabolism, rheological blood properties (viscosity of the whole blood, hematocrit, viscosity of erythrocyte and plasma suspension), microcirculation and compensatory responses of the body. Identification of oxygen transport disorders and hemorheological shifts, determination of their nature, intensity as well as of the mechanism by which they occur make it possible to form a genuine basis for effective differentiated correction of the abnormalities of the blood rheological properties and tissue hypoxia, and favours stabilization of microangiopathies in patients with diabetes mellitus.