[Desynchronization of circadian rhythms of the oxygen balance in the tissues and rheological properties of the blood in type I diabetes mellitus].

Circadian rhythms of tissue oxygen balance and blood rheological properties were investigated in 40 patients with insulin dependent diabetes mellitus. The syndrome of blood hyperviscosity determined by a rise of the level of packed cell volume and blood viscosity developed in decompensation of diabetes mellitus, resulting in desynchronization of packed cell volume. Blood viscosity rhythm was preserved but fluctuation ranges were sharply on an increase. Tissue oxygen balance disorders were manifested in the development of tissue hypoxia leading to rhythm desynchronization. Progression of the above disorders were noted in parallel with growing severity of disease. Compensation of diabetes mellitus was accompanied by moderate hyperviscosity and disappearance of tissue hypoxia in the morning. Fluctuation rhythm of all studied indices returned to normal with the exception of packed cell volume. Preserved blood hyperviscosity and increasing tissue hypoxia at night indicated stable disturbance of hemorheological properties and tissue oxygen balance. These disorders could lead to the development of another decompensation of diabetes mellitus.