Laboratory of Genetics, Immunology and Human Pathology, Faculty of Sciences of Tunis, El Manar University, Manar I, 1060 Tunis, Tunisia.
Forensic Sci Int Genet. 2011 Jun;5(3):e45-7. doi: 10.1016/j.fsigen.2010.07.007. Epub 2010 Sep 17.
A total of 149 unrelated and healthy individuals comprising: Tunisian Berbers, Tunisians with Andalusian origin and Libyans were typed with the SNPforID 34-plex ancestry informative marker (AIM) SNP panel. Results of 31 of the 34 SNPs are presented and no deviations from Hardy-Weinberg equilibrium were observed after Bonferroni correction (p=0.00161) except rs722098 (p=0.0000). Comparisons of allele frequencies showed high divergence values between North Africans and Europeans (δ>30%) in markers: rs4540055 (allele A) and rs16891982. Our study adds data that can be used as training set genotypes for future ancestry investigations in forensic cases and suggests these AIM-SNPs can successfully differentiate North Africans and Mediterranean Europeans.
对 149 名无亲缘关系的健康个体进行了基因分型，这些个体包括：突尼斯柏柏尔人、具有安达卢西亚血统的突尼斯人和利比亚人，使用的是 SNPforID 34 plex 祖先信息标记（AIM）SNP 面板。呈现了 34 个 SNP 中的 31 个 SNP 的结果，并且在经过 Bonferroni 校正（p=0.00161）后，除了 rs722098（p=0.0000）之外，没有观察到 Hardy-Weinberg 平衡的偏差。等位基因频率的比较显示，在标记 rs4540055（等位基因 A）和 rs16891982 中，北非人和欧洲人之间存在高度的离散值（δ>30%）。我们的研究增加了可以用作未来法医案例中祖先研究的训练集基因型的数据，并表明这些 AIM-SNPs 可以成功地区分北非人和地中海欧洲人。
