Medical Genetic Laboratory, Universidad Tecnológica de Pereira, Colombia.
Forensic Sci Int Genet. 2009 Dec;4(1):e9-10. doi: 10.1016/j.fsigen.2008.12.003. Epub 2009 Jan 24.
A set of autosomal single nucleotide polymorphism (SNP) loci was analyzed using the 52-plex assay previously described by Sanchez et al. [J.J. Sanchez, C. Phillips, C. Borsting, K. Balogh, M. Bogus, M. Fondevila, C.D. Harrison, E. Musgrave-Brown, A. Salas, D. Syndercombe-Court, P.M. Schneider, A. Carracedo, N. Morling, A multiplex assay with 52 single nucleotide polymorphisms for human identification, Electrophoresis 27 (2006) 1713-1724] in 140 samples of unrelated individuals born in the Colombian regions of, Risaralda, Caldas, Quindio, Antioquia, Tolima and Valle, and 164 samples of unrelated individuals with declared Native American ancestry from Colombia. Allele frequencies and statistical parameters of forensic interest are presented for the 52 SNPs. All loci were in agreement with Hardy-Weinberg equilibrium while comparisons with population samples of Argentina, Portugal, Spain, Mozambique, and Taiwan revealed significant differences in allele frequency distributions.
采用 Sanchez 等人先前描述的 52 重扩增检验分析了一组常染色体单核苷酸多态性 (SNP) 位点[J.J. Sanchez, C. Phillips, C. Borsting, K. Balogh, M. Bogus, M. Fondevila, C.D. Harrison, E. Musgrave-Brown, A. Salas, D. Syndercombe-Court, P.M. Schneider, A. Carracedo, N. Morling, A multiplex assay with 52 single nucleotide polymorphisms for human identification, Electrophoresis 27 (2006) 1713-1724]。该分析共纳入 140 名出生于哥伦比亚里萨拉尔达、卡尔达斯、金迪奥、安蒂奥基亚、托利马和瓦莱等地区的无关个体样本，以及 164 名来自哥伦比亚的、宣称有美洲原住民血统的无关个体样本。报告了 52 个 SNP 的等位基因频率和具有法医学意义的统计参数。所有基因座均符合 Hardy-Weinberg 平衡，与来自阿根廷、葡萄牙、西班牙、莫桑比克和中国台湾地区的人群样本比较，发现等位基因频率分布存在显著差异。
