Oyanagi K, Takahashi H, Wakabayashi K, Ikuta F
Department of Neuropathology, Niigata University, Japan.
Brain Res. 1988 Aug 23;458(2):218-23. doi: 10.1016/0006-8993(88)90464-7.
In order to evaluate the quantitative changes in the neostriatum in progressive supranuclear palsy (PSP), sections of the caudate head (CN) and putamen (PT) from 4 PSP patients were stained with Klüver-Barrera, and the cell body and nuclear area of the neurons were measured by a digitizer. Obtained results were compared to those of 6 age-matched control and 4 Alzheimer's disease and senile dementia of Alzheimer type (AD/SDAT) subjects which were previously reported. The number of large neurons (nuclear area greater than 101 microns 2) in PSP was about 40% (P less than 0.01) and 30% (P less than 0.01) of that of the controls in CN and PT, respectively. In contrast, the number of small neurons in PSP (nuclear area less than 100 microns 2) was well preserved. The values were quite similar to those in AD/SDAT. The implications and possible significance are discussed.
为了评估进行性核上性麻痹（PSP）新纹状体的定量变化，对4例PSP患者的尾状核头部（CN）和壳核（PT）切片进行Klüver-Barrera染色，并用数字转换器测量神经元的细胞体和核面积。将所得结果与先前报道的6例年龄匹配的对照以及4例阿尔茨海默病和阿尔茨海默型老年性痴呆（AD/SDAT）受试者的结果进行比较。PSP中大型神经元（核面积大于101平方微米）的数量分别约为CN和PT中对照组的40%（P<0.01）和30%（P<0.01）。相比之下，PSP中小神经元（核面积小于100平方微米）的数量保存良好。这些值与AD/SDAT中的值非常相似。对其意义及可能的重要性进行了讨论。
