Hahn-Zoric M, Fulconis F, Minoli I, Moro G, Carlsson B, Böttiger M, Räihä N, Hanson L A
Department of Clinical Immunology, University of Göteborg, Sweden.
Acta Paediatr Scand. 1990 Dec;79(12):1137-42. doi: 10.1111/j.1651-2227.1990.tb11401.x.
The vaccine response to poliovirus, diphtheria and tetanus toxoids in relation to protein intake was studied in infants, either breast-fed or given low (1.1 g/100 ml) or conventional (1.5 g/100 ml) protein formula. Serum, saliva and faeces antibodies were measured by the enzyme-linked immunosorbent assay. Neutralizing poliovirus antibodies were determined. The serum, saliva and faeces antibody responses in the two formula-fed groups of infants did not differ significantly, but for the low protein formula group which had significantly higher serum neutralizing titres to poliovirus after the second vaccine dose than the conventional formula group. However, the breast-fed group had significantly higher antibody levels than the two formula-fed groups together: serum IgG to diphtheria toxoid (p less than 0.01) and serum neutralization of poliovirus (p less than 0.001) at 21-40 months of age, saliva secretory IgA to tetanus (p less than 0.01), diphtheria toxoid (p less than 0.01) and poliovirus (p less than 0.05), as well as faecal IgM to tetanus toxoid (p less than 0.05) and poliovirus (p less than 0.01 and p less than 0.05) at 3 and 4 months of age. Breast-fed infants thus showed better serum and secretory responses to peroral and parenteral vaccines than the formula-fed, whether with a conventional or low protein content.
研究了母乳喂养或食用低蛋白（1.1克/100毫升）或常规蛋白（1.5克/100毫升）配方奶粉的婴儿对脊髓灰质炎病毒、白喉和破伤风类毒素疫苗的反应。通过酶联免疫吸附测定法测量血清、唾液和粪便中的抗体。测定了脊髓灰质炎病毒中和抗体。两组配方奶粉喂养的婴儿的血清、唾液和粪便抗体反应没有显著差异，但低蛋白配方奶粉组在第二次疫苗接种后对脊髓灰质炎病毒的血清中和滴度显著高于常规配方奶粉组。然而，母乳喂养组的抗体水平明显高于两组配方奶粉喂养组之和：在21至40个月大时，血清抗白喉类毒素IgG（p小于0.01）和脊髓灰质炎病毒血清中和抗体（p小于0.001）；在3和4个月大时，唾液分泌型抗破伤风IgA（p小于0.01）、抗白喉类毒素IgA（p小于0.01）和抗脊髓灰质炎病毒IgA（p小于0.05），以及粪便抗破伤风类毒素IgM（p小于0.05）和抗脊髓灰质炎病毒IgM（p小于0.01和p小于0.05）。因此，无论配方奶粉的蛋白含量是常规的还是低的，母乳喂养的婴儿对口服和注射疫苗的血清和分泌反应都比配方奶粉喂养的婴儿更好。
