Riccardo Federica, Réal Aline, Voena Claudia, Chiarle Roberto, Cavallo Federica, Barutello Giuseppina
Department of Molecular Biotechnology and Health Sciences, Molecular Biotechnology Center, University of Torino, Torino 10126, Italy.
Department of Molecular Biotechnology and Health Sciences, Center for Experimental Research and Medical Studies, University of Torino, Torino 10126, Italy.
Vaccines (Basel). 2017 Aug 1;5(3):20. doi: 10.3390/vaccines5030020.
The continuous evolution in preventive medicine has anointed vaccination a versatile, human-health improving tool, which has led to a steady decline in deaths in the developing world. Maternal immunization represents an incisive step forward for the field of vaccination as it provides protection against various life-threatening diseases in pregnant women and their children. A number of studies to improve prevention rates and expand protection against the largest possible number of infections are still in progress. The complex unicity of the mother-infant interaction, both during and after pregnancy and which involves immune system cells and molecules, is an able partner in the success of maternal immunization, as intended thus far. Interestingly, new studies have shed light on the versatility of maternal immunization in protecting infants from non-infectious related diseases, such as allergy, asthma and congenital metabolic disorders. However, barely any attempt at applying maternal immunization to the prevention of childhood cancer has been made. The most promising study reported in this new field is a recent proof of concept on the efficacy of maternal immunization in protecting cancer-prone offspring against mammary tumor progression. New investigations into the possibility of exploiting maternal immunization to prevent the onset and/or progression of neuroblastoma, one of the most common childhood malignancies, are therefore justified. Maternal immunization is presented in a new guise in this review. Attention will be focused on its versatility and potential applications in preventing tumor progression in neuroblastoma-prone offspring.
预防医学的持续发展使疫苗接种成为一种多功能的、改善人类健康的工具，这导致发展中世界的死亡人数稳步下降。孕产妇免疫接种是疫苗接种领域向前迈出的关键一步，因为它能为孕妇及其子女预防各种危及生命的疾病。目前仍有一些研究正在进行，旨在提高预防率并扩大对尽可能多的感染的防护。母婴互动在孕期及产后具有复杂的独特性，涉及免疫系统细胞和分子，正如迄今为止所预期的那样，它是孕产妇免疫接种成功的有力伙伴。有趣的是，新的研究揭示了孕产妇免疫接种在保护婴儿免受非感染性相关疾病（如过敏、哮喘和先天性代谢紊乱）方面的多功能性。然而，几乎没有人尝试将孕产妇免疫接种应用于预防儿童癌症。该新领域报道的最有前景的研究是最近一项关于孕产妇免疫接种在保护易患癌症的后代预防乳腺肿瘤进展方面疗效的概念验证。因此，对利用孕产妇免疫接种预防最常见的儿童恶性肿瘤之一神经母细胞瘤的发病和/或进展的可能性进行新的研究是合理的。在本综述中，孕产妇免疫接种呈现出一种新的面貌。我们将重点关注其在预防易患神经母细胞瘤的后代肿瘤进展方面的多功能性和潜在应用。
