Department of Psychology, Louisiana State University, 236 Audubon Hall, Baton Rouge, LA 70808, USA.
J Psychiatr Res. 2011 Apr;45(4):548-54. doi: 10.1016/j.jpsychires.2010.08.013. Epub 2010 Sep 18.
Cannabis use is associated with onset of psychosis in individuals vulnerable for developing schizophrenia-spectrum disorders. The present study addressed three knowledge gaps pertaining to this issue: 1) clarifying the incidence of cannabis use in schizotypal individuals, 2) examining how cannabis use is related to psychosocial and physiological problems in schizotypy and interest in treatment, and 3) examining how cannabis use is associated with positive, negative and disorganization features of schizotypy. Scores from a measure of schizotypal traits were used to trichotomize 1665 young adults into schizotypy (top 5% of scorers), non-schizotypy (bottom 50% of scorers) and "unconventional" (scorers within the 50th to 85th percentile) groups. Nearly a quarter of the schizotypy group endorsed cannabis use at least weekly, a rate nearly two to four times that of the other groups. The schizotypy group also reported a much greater frequency of cannabis-related problems compared to the other groups. Despite this, interest in treatment for cannabis use in the schizotypy group was not elevated. Interestingly, 85% of individuals in the schizotypy group reported interest in psychological/psychiatric treatment more generally. Cannabis use was not associated with abnormal patterns of positive or disorganized schizotypy traits in the schizotypy group relative to the other groups. However, cannabis use was associated with lower severity of negative traits. Implications of these results are discussed.
大麻使用与易患精神分裂谱系障碍的个体的精神病发病有关。本研究解决了与该问题相关的三个知识空白:1)阐明精神分裂样个体中大麻使用的发生率,2)检查大麻使用如何与精神分裂样特质中的社会心理和生理问题以及对治疗的兴趣相关,3)检查大麻使用如何与精神分裂样特质的阳性、阴性和紊乱特征相关。使用精神分裂样特质的测量得分将 1665 名年轻人分为精神分裂样特质(得分最高的 5%)、非精神分裂样特质(得分最低的 50%)和“非传统”特质(得分在 50%到 85%之间)。将近四分之一的精神分裂样特质个体至少每周一次使用大麻,这一比例是其他两组的近两到四倍。与其他两组相比,精神分裂样特质组报告的大麻相关问题的频率也高得多。尽管如此,精神分裂样特质组对大麻使用治疗的兴趣并没有增加。有趣的是,精神分裂样特质组中有 85%的人更普遍地报告对心理/精神病治疗感兴趣。与其他两组相比,精神分裂样特质组的大麻使用与异常的阳性或紊乱精神分裂样特质模式无关。然而,大麻使用与阴性特征的严重程度降低有关。讨论了这些结果的含义。