用于癌症检测的靶向纳米制剂。
Targeted nanoagents for the detection of cancers.
机构信息
Center for Systems Biology, Harvard Medical School and Massachusetts General Hospital, Boston, MA 02114, USA.
出版信息
Mol Oncol. 2010 Dec;4(6):511-28. doi: 10.1016/j.molonc.2010.08.003. Epub 2010 Sep 8.
Abstract
Nanotechnology has enabled a renaissance in the diagnosis of cancers. This is due, in part to the ability to develop agents bearing multiple functionalities, including those utilized for targeting, imaging, and therapy, allowing for the tailoring of the properties of the nanomaterials. Whereas many nanomaterials exhibit localization to diseased tissues via intrinsic targeting, the addition of targeting ligands, such as antibodies, peptides, aptamers, and small molecules, facilitates far more sensitive cancer detection. As such, this review focuses upon some of the most poignant examples of the utility of affinity ligand targeted nanoagents in the detection of cancer.
摘要
纳米技术使得癌症诊断领域出现了复兴。这部分是由于能够开发出具有多种功能的试剂，包括用于靶向、成像和治疗的功能，从而能够定制纳米材料的特性。虽然许多纳米材料通过内在靶向作用定位到病变组织，但添加靶向配体，如抗体、肽、适体和小分子，可促进更敏感的癌症检测。因此，本文重点介绍了一些最引人注目的例子，说明了亲和配体靶向纳米试剂在癌症检测中的应用。
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