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SQSTM1-NUP214: a new gene fusion in adult T-cell acute lymphoblastic leukemia.

作者信息

Gorello Paolo, La Starza Roberta, Di Giacomo Danika, Messina Monica, Puzzolo Maria Cristina, Crescenzi Barbara, Santoro Alessandra, Chiaretti Sabina, Mecucci Cristina

出版信息

Haematologica. 2010 Dec;95(12):2161-3. doi: 10.3324/haematol.2010.029769. Epub 2010 Sep 17.

DOI:10.3324/haematol.2010.029769
PMID:20851865
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2995577/
Abstract
摘要

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Haematologica. 2010 Dec;95(12):2161-3. doi: 10.3324/haematol.2010.029769. Epub 2010 Sep 17.
2
SET-NUP214 fusion in acute myeloid leukemia- and T-cell acute lymphoblastic leukemia-derived cell lines.急性髓系白血病和 T 细胞急性淋巴细胞白血病源性细胞系中的 SET-NUP214 融合。
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The characteristics and prognostic significance of the SET-CAN/NUP214 fusion gene in hematological malignancies: A systematic review.SET-CAN/NUP214 融合基因在血液系统恶性肿瘤中的特征及预后意义：系统评价。
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Mutations of PHF6 are associated with mutations of NOTCH1, JAK1 and rearrangement of SET-NUP214 in T-cell acute lymphoblastic leukemia.PHF6 突变与 T 细胞急性淋巴细胞白血病中的 NOTCH1、JAK1 突变和 SET-NUP214 重排相关。
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[Expression of SET-NUP214 fusion gene in patients with T-cell acute lymphoblastic leukemia and its clinical significance].[SET-NUP214融合基因在T细胞急性淋巴细胞白血病患者中的表达及其临床意义]
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fusion genes in acute leukemias: genetic characterization of rare cases.急性白血病中的融合基因：罕见病例的遗传学特征
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The nuclear pore proteins Nup88/214 and T-cell acute lymphatic leukemia-associated NUP214 fusion proteins regulate Notch signaling.核孔蛋白 Nup88/214 和 T 细胞急性淋巴细胞白血病相关的 NUP214 融合蛋白调节 Notch 信号通路。
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NUP214 in Leukemia: It's More than Transport.NUP214 在白血病中的作用：不止是运输。
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本文引用的文献

1
Gene expression profiling identifies a subset of adult T-cell acute lymphoblastic leukemia with myeloid-like gene features and over-expression of miR-223.基因表达谱分析确定了一组具有髓样基因特征和 miR-223 过表达的成人 T 细胞急性淋巴细胞白血病亚群。
Haematologica. 2010 Jul;95(7):1114-21. doi: 10.3324/haematol.2009.015099. Epub 2010 Apr 23.
2
Rescue of genomic information in adult acute lymphoblastic leukaemia (ALL) with normal/failed cytogenetics: a GIMEMA centralized biological study.成人急性淋巴细胞白血病（ALL）中具有正常/失败细胞遗传学的基因组信息挽救：一个 GIMEMA 集中的生物学研究。
Br J Haematol. 2010 Apr;149(1):70-8. doi: 10.1111/j.1365-2141.2009.08056.x. Epub 2010 Jan 11.
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Combined interphase fluorescence in situ hybridization elucidates the genetic heterogeneity of T-cell acute lymphoblastic leukemia in adults.联合间期荧光原位杂交阐明了成人 T 细胞急性淋巴细胞白血病的遗传异质性。
Haematologica. 2010 Jan;95(1):79-86. doi: 10.3324/haematol.2009.010413.
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Nuclear pore proteins and cancer.核孔蛋白与癌症
Semin Cell Dev Biol. 2009 Jul;20(5):620-30. doi: 10.1016/j.semcdb.2009.03.003. Epub 2009 Mar 18.
5
Increased signaling through p62 in the marrow microenvironment increases myeloma cell growth and osteoclast formation.骨髓微环境中通过p62的信号增强会增加骨髓瘤细胞的生长和破骨细胞的形成。
Blood. 2009 May 14;113(20):4894-902. doi: 10.1182/blood-2008-08-173948. Epub 2009 Mar 12.
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Hypoxia-activated autophagy accelerates degradation of SQSTM1/p62.缺氧激活的自噬加速SQSTM1/p62的降解。
Oncogene. 2009 Jan 22;28(3):334-44. doi: 10.1038/onc.2008.392. Epub 2008 Oct 20.
7
FIP1L1-PDGFRA in chronic eosinophilic leukemia and BCR-ABL1 in chronic myeloid leukemia affect different leukemic cells.慢性嗜酸性粒细胞白血病中的FIP1L1-PDGFRA和慢性髓性白血病中的BCR-ABL1影响不同的白血病细胞。
Leukemia. 2007 Mar;21(3):397-402. doi: 10.1038/sj.leu.2404510. Epub 2007 Jan 11.
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Genetic insights in the pathogenesis of T-cell acute lymphoblastic leukemia.T细胞急性淋巴细胞白血病发病机制的遗传学见解
Haematologica. 2005 Aug;90(8):1116-27.
9
Aberrant intracellular localization of SET-CAN fusion protein, associated with a leukemia, disorganizes nuclear export.与一种白血病相关的SET-CAN融合蛋白异常的细胞内定位会扰乱核输出。
Int J Cancer. 2004 Sep 10;111(4):501-7. doi: 10.1002/ijc.20296.
10
Recurrent mutation of the gene encoding sequestosome 1 (SQSTM1/p62) in Paget disease of bone.骨佩吉特病中编码聚集体小体1（SQSTM1/p62）的基因反复突变。
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