Rush University Medical Center, Chicago, Illinois 60612, USA.
Arthritis Care Res (Hoboken). 2010 Sep;62(9):1287-93. doi: 10.1002/acr.20200.
To test the hypothesis that the number of areas of musculoskeletal pain reported is related to incident disability.
Subjects included 898 older persons from the Rush Memory and Aging Project without dementia, stroke, or Parkinson's disease at baseline. All participants underwent detailed baseline evaluation of self-reported pain in the neck or back, hands, hips, knees, or feet, as well as annual self-reported assessments of instrumental activities of daily living (IADLs), basic activities of daily living (ADLs), and mobility disability. Mobility disability was also assessed using a performance-based measure.
The average followup was 5.6 years. Using a series of proportional hazards models that controlled for age, sex, and education, the risk of IADL disability increased by ∼10% for each additional painful area reported (hazard ratio [HR] 1.10, 95% confidence interval [95% CI] 1.01-1.20) and the risk of ADL disability increased by ∼20% for each additional painful area (HR 1.20, 95% CI 1.11-1.31). The association with self-report mobility disability did not reach significance (HR 1.09, 95% CI 0.99-1.20). However, the risk of mobility disability based on gait speed performance increased by ∼13% for each additional painful area (HR 1.13, 95% CI 1.04-1.22). These associations did not vary by age, sex, or education and were unchanged after controlling for several potential confounding variables including body mass index, physical activity, cognition, depressive symptoms, vascular risk factors, and vascular diseases.
Among nondisabled community-dwelling older adults, the risk of disability increases with the number of areas reported with musculoskeletal pain.
验证下述假设,即报告的肌肉骨骼疼痛部位数量与新发残疾有关。
研究对象为 Rush 记忆与衰老项目中的 898 名无痴呆、中风或帕金森病的老年人。所有参与者均接受了详细的基线评估,内容为颈部或背部、手部、臀部、膝盖或脚部的自我报告疼痛,以及每年一次的工具性日常生活活动(IADL)、基本日常生活活动(ADL)和移动性残疾的自我报告评估。移动性残疾也通过基于表现的测量进行评估。
平均随访时间为 5.6 年。使用一系列控制年龄、性别和教育的比例风险模型,报告的疼痛部位每增加一个,IADL 残疾的风险增加约 10%(风险比 [HR] 1.10,95%置信区间 [95%CI] 1.01-1.20),ADL 残疾的风险增加约 20%(HR 1.20,95%CI 1.11-1.31)。与自我报告的移动性残疾的相关性没有达到显著水平(HR 1.09,95%CI 0.99-1.20)。然而,基于步态速度表现的移动性残疾风险每增加一个疼痛部位,增加约 13%(HR 1.13,95%CI 1.04-1.22)。这些关联不受年龄、性别或教育的影响,并且在控制了包括体重指数、身体活动、认知、抑郁症状、血管危险因素和血管疾病在内的几种潜在混杂变量后仍然不变。
在无残疾的社区居住的老年人中,报告的肌肉骨骼疼痛部位数量越多,残疾风险越高。