Weng Yiming, Guo Xia, Gregory Richard, Xie Dong
Department of Biomedical Engineering, Purdue School of Engineering and Technology, Indiana University-Purdue University at Indianapolis, Indianapolis, IN 46202, USA.
Eur J Oral Sci. 2010 Oct;118(5):531-4. doi: 10.1111/j.1600-0722.2010.00770.x.
This study reports the synthesis and evaluation of a novel non-leachable poly(quaternary ammonium salt) (PQAS)-containing antibacterial glass-ionomer cement. Fuji II LC cement was used for comparison. Compressive strength (CS) and Streptococcus mutans viability were used to evaluate strength and antibacterial activity, respectively. All specimens were conditioned in distilled water at 37 degrees C before testing. After the addition of 1-30% PQAS, both cements showed a reduction in CS, of 25-95% for Fuji II LC and 13-78% for the experimental cement, and a reduction in S. mutans viability, of 40-79% for Fuji II LC and 40-91% for the experimental cement. The experimental cement showed less CS reduction and higher antibacterial activity compared with Fuji II LC. The result also indicates that the cements are permanently antibacterial, with no leaching of PQAS. It appears that the experimental cement is a clinically attractive dental restorative that can be potentially used for longlasting restorations as a result of its high mechanical strength and permanent antibacterial function.
本研究报告了一种新型含不可浸出聚季铵盐（PQAS）的抗菌玻璃离子水门汀的合成与评价。使用富士II LC水门汀作为对照。分别采用抗压强度（CS）和变形链球菌活力来评估强度和抗菌活性。所有试样在测试前于37℃蒸馏水中养护。添加1 - 30% PQAS后，两种水门汀的CS均降低，富士II LC降低25 - 95%，实验性水门汀降低13 - 78%；变形链球菌活力也降低，富士II LC降低40 - 79%，实验性水门汀降低40 - 91%。与富士II LC相比，实验性水门汀的CS降低较少且抗菌活性更高。结果还表明，这些水门汀具有永久性抗菌作用，PQAS无浸出。实验性水门汀似乎是一种具有临床吸引力的牙科修复材料，由于其高机械强度和永久性抗菌功能，有可能用于长期修复。
