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基于季铵盐的生物医学材料：最新进展、毒理学方面及抗菌耐药性。

Quaternary ammonium-based biomedical materials: State-of-the-art, toxicological aspects and antimicrobial resistance.

作者信息

Jiao Yang, Niu Li-Na, Ma Sai, Li Jing, Tay Franklin R, Chen Ji-Hua

机构信息

State Key Laboratory of Military Stomatology & National Clinical Research Center for Oral Diseases & Shaanxi Key Laboratory of Oral Diseases, Department of Prosthodontics, School of Stomatology, The Fourth Military Medical University, 710032, Xi'an, Shaanxi, China.

Department of Stomatology, PLA Army General Hospital, 100700, Beijing, China.

出版信息

Prog Polym Sci. 2017 Aug;71:53-90. doi: 10.1016/j.progpolymsci.2017.03.001. Epub 2017 Mar 12.

DOI:10.1016/j.progpolymsci.2017.03.001
PMID:32287485
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7111226/
Abstract

Microbial infections affect humans worldwide. Many quaternary ammonium compounds have been synthesized that are not only antibacterial, but also possess antifungal, antiviral and anti-matrix metalloproteinase capabilities. Incorporation of quaternary ammonium moieties into polymers represents one of the most promising strategies for preparation of antimicrobial biomaterials. Various polymerization techniques have been employed to prepare antimicrobial surfaces with quaternary ammonium functionalities; in particular, syntheses involving controlled radical polymerization techniques enable precise control over macromolecular structure, order and functionality. Although recent publications report exciting advances in the biomedical field, some of these technological developments have also been accompanied by potential toxicological and antimicrobial resistance challenges. Recent evidenced-based data on the biomedical applications of antimicrobial quaternary ammonium-containing biomaterials that are based on randomized human clinical trials, the golden standard in contemporary medicinal science, are included in the present review. This should help increase visibility, stimulate debates and spur conversations within a wider scientific community on the implications and plausibility for future developments of quaternary ammonium-based antimicrobial biomaterials.

摘要

微生物感染影响着全球人类。已经合成了许多季铵化合物，它们不仅具有抗菌作用，还具有抗真菌、抗病毒和抗基质金属蛋白酶的能力。将季铵部分引入聚合物是制备抗菌生物材料最有前景的策略之一。已经采用了各种聚合技术来制备具有季铵官能团的抗菌表面；特别是，涉及可控自由基聚合技术的合成能够精确控制大分子的结构、序列和官能团。尽管最近的出版物报道了生物医学领域令人兴奋的进展，但其中一些技术发展也伴随着潜在的毒理学和抗菌耐药性挑战。本综述纳入了基于当代医学科学的黄金标准——随机人体临床试验的抗菌含季铵生物材料生物医学应用的最新循证数据。这应该有助于提高关注度，激发更广泛科学界内关于季铵基抗菌生物材料未来发展的影响和合理性的辩论和对话。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8fc4/7111226/48d0ef1129eb/gr17_lrg.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8fc4/7111226/acbb9b1598a7/gr1_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8fc4/7111226/cbff8c7899c6/gr2_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8fc4/7111226/198957a01f74/gr3_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8fc4/7111226/5331438a52b8/gr4_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8fc4/7111226/35da9116729a/gr5_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8fc4/7111226/2c49d6171cd9/gr6_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8fc4/7111226/71e6c8e47892/gr7_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8fc4/7111226/3c0165ea0865/gr8_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8fc4/7111226/790762da8cac/gr9_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8fc4/7111226/86f00c82165b/gr10_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8fc4/7111226/aaac0510a76a/gr11_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8fc4/7111226/41d066ae3185/gr12_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8fc4/7111226/51cb8810e93a/gr13_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8fc4/7111226/bb08d792f25e/gr14_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8fc4/7111226/2f2403bdab8d/gr15_lrg.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8fc4/7111226/48d0ef1129eb/gr17_lrg.jpg

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