Department of Biomedical Engineering, Purdue School of Engineering and Technology, Indiana University-Purdue University at Indianapolis, 723 West Michigan Street, IN 46202, USA.
Acta Biomater. 2012 Aug;8(8):3153-60. doi: 10.1016/j.actbio.2012.04.038. Epub 2012 Apr 30.
A novel furanone derivative and a polyacid constructed from it were synthesized, characterized and formulated into experimental high strength cements. The compressive strength (CS) and Streptococcus mutans viability were used to evaluate the mechanical strength and antibacterial activity of the cements. The effect of human saliva and aging were investigated. The antibacterial activity against Lactobacillus sp. and cytotoxicity to human pulp cells were also evaluated. The results show that all the formulated furanone-containing cements showed antibacterial activity, with an initial reduction in CS. The effect of the furanone derivative loading was significant. Increasing loading enhanced the antibacterial activity but reduced the initial CS of the formed cements. The derivative showed antibacterial activity against both S. mutans and Lactobacillus sp. Human saliva did not affect the antibacterial activity of the cement. The cytotoxicity study with human dental pulp cells shows that the furanone-modified cement was biocompatible. A 30 day aging study indicated that the cements may have long-lasting antibacterial activity. Within the limitations of this study it appears that the experimental cement could be a clinically attractive dental restorative due to its high mechanical strength and antibacterial function.
合成了一种新型呋喃酮衍生物及其多酸，并对其进行了表征和制剂成实验性高强度水泥。采用抗压强度（CS）和变形链球菌活力评估水泥的机械强度和抗菌活性。研究了人唾液和老化的影响。还评估了对乳酸杆菌和人牙髓细胞的细胞毒性的抗菌活性。结果表明，所有含呋喃酮的配方水泥均表现出抗菌活性，CS 最初降低。呋喃酮衍生物的负载效果显著。增加负载量可增强抗菌活性，但会降低形成的水泥的初始 CS。该衍生物对变形链球菌和乳酸杆菌均具有抗菌活性。人唾液不会影响水泥的抗菌活性。用人牙髓细胞进行的细胞毒性研究表明，呋喃酮改性水泥具有生物相容性。30 天的老化研究表明，该水泥可能具有持久的抗菌活性。在本研究的限制范围内，由于实验性水泥具有高强度机械性能和抗菌功能，因此它可能成为一种有吸引力的临床牙科修复体。
