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采用间接酶联免疫吸附测定法对人脐带血清中B族链球菌抗体(血清型Ia、Ib、II和III)进行定量检测。

Quantitative measurement of group B streptococcal antibodies (serotypes Ia, Ib, II and III) in human cord sera by the indirect enzyme-linked immunosorbent assay.

作者信息

Ratei R, Kainer F, Hahn H

机构信息

Institut für Medizinische Mikrobiologie und Infektionsimmunologie, Freie Universität Berlin.

出版信息

Zentralbl Bakteriol. 1990 Nov;274(2):227-38. doi: 10.1016/s0934-8840(11)80105-2.

Abstract

Cervical and vaginal carriage of group B streptococci (GBS) is normally associated with an appropriate immune response confining these organisms to a commensal state in this human habitat. A newly developed indirect enzyme-linked immunosorbent assay compares the antibody responses against two antigen preparations of GBS-serotypes Ia, Ib, II and III in the cord sera of cervico-vaginal GBS-carriers and non-carriers during pregnancy. Antibody responses in GBS-positive women against both antigen preparations were found to be significantly higher than in GBS-negative women (p less than 0.005). Antibody levels towards the EDTA-antigen were markedly lower than levels for the HCl-antigen thus indicating two different antibody responses.

摘要

B族链球菌(GBS)在宫颈和阴道的定植通常与适当的免疫反应相关,可将这些微生物限制在人体这个栖息地的共生状态。一种新开发的间接酶联免疫吸附测定法比较了妊娠期间宫颈阴道GBS携带者和非携带者脐带血清中针对GBS血清型Ia、Ib、II和III的两种抗原制剂的抗体反应。发现GBS阳性女性对两种抗原制剂的抗体反应均显著高于GBS阴性女性(p小于0.005)。针对EDTA抗原的抗体水平明显低于HCl抗原的水平,这表明存在两种不同的抗体反应。

相似文献

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Seroepidemiology of group B streptococcus type III colonization at delivery.
J Infect Dis. 1989 Jun;159(6):1139-42. doi: 10.1093/infdis/159.6.1139.

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