• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

Is P-glycoprotein involved in amyloid-β elimination across the blood-brain barrier in Alzheimer's disease?

作者信息

Ohtsuki S, Ito S, Terasaki T

机构信息

Division of Membrane Transport and Drug Targeting, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan.

出版信息

Clin Pharmacol Ther. 2010 Oct;88(4):443-5. doi: 10.1038/clpt.2010.160.

DOI:10.1038/clpt.2010.160
PMID:20856239
Abstract
摘要

相似文献

1
Is P-glycoprotein involved in amyloid-β elimination across the blood-brain barrier in Alzheimer's disease?P-糖蛋白是否参与阿尔茨海默病中β-淀粉样蛋白通过血脑屏障的清除过程?
Clin Pharmacol Ther. 2010 Oct;88(4):443-5. doi: 10.1038/clpt.2010.160.
2
MDR1-P-glycoprotein (ABCB1)-mediated disposition of amyloid-β peptides: implications for the pathogenesis and therapy of Alzheimer's disease.MDR1-P-糖蛋白(ABCB1)介导的淀粉样β肽处置:对阿尔茨海默病发病机制和治疗的影响。
Clin Pharmacol Ther. 2010 Oct;88(4):441-3. doi: 10.1038/clpt.2010.126.
3
Blood-brain barrier P-glycoprotein function in Alzheimer's disease.阿尔茨海默病中的血脑屏障 P-糖蛋白功能。
Brain. 2012 Jan;135(Pt 1):181-9. doi: 10.1093/brain/awr298. Epub 2011 Nov 26.
4
P-glycoprotein expression and amyloid accumulation in human aging and Alzheimer's disease: preliminary observations.人类衰老和阿尔茨海默病中P-糖蛋白表达与淀粉样蛋白积累:初步观察
Neurobiol Aging. 2015 Sep;36(9):2475-82. doi: 10.1016/j.neurobiolaging.2015.05.020. Epub 2015 Jun 6.
5
MDR1-P-Glycoprotein (ABCB1) Mediates Transport of Alzheimer's amyloid-beta peptides--implications for the mechanisms of Abeta clearance at the blood-brain barrier.多药耐药蛋白1-P-糖蛋白(ABCB1)介导阿尔茨海默病β淀粉样肽的转运——对血脑屏障处β淀粉样蛋白清除机制的启示。
Brain Pathol. 2007 Oct;17(4):347-53. doi: 10.1111/j.1750-3639.2007.00075.x. Epub 2007 Jul 4.
6
Design and evaluation of a 6-mer amyloid-beta protein derived phage display library for molecular targeting of amyloid plaques in Alzheimer's disease: Comparison with two cyclic heptapeptides derived from a randomized phage display library.用于阿尔茨海默病淀粉样斑块分子靶向的 6 肽淀粉样β蛋白衍生噬菌体展示文库的设计与评价:与源自随机噬菌体展示文库的两个环状七肽的比较。
Peptides. 2011 Jun;32(6):1232-43. doi: 10.1016/j.peptides.2011.04.026. Epub 2011 May 6.
7
Involvement of insulin-degrading enzyme in insulin- and atrial natriuretic peptide-sensitive internalization of amyloid-β peptide in mouse brain capillary endothelial cells.胰岛素降解酶参与胰岛素和心钠肽敏感的淀粉样β肽在鼠脑毛细血管内皮细胞中的内化。
J Alzheimers Dis. 2014;38(1):185-200. doi: 10.3233/JAD-122077.
8
Transport of Alzheimer disease amyloid-beta-binding D-amino acid peptides across an in vitro blood-brain barrier model.阿尔茨海默病淀粉样β结合 D-氨基酸肽在体外血脑屏障模型中的转运。
Rejuvenation Res. 2010 Apr-Jun;13(2-3):210-3. doi: 10.1089/rej.2009.0926.
9
Inhibition of ADAM10 promotes the clearance of Aβ across the BBB by reducing LRP1 ectodomain shedding.抑制ADAM10通过减少低密度脂蛋白受体相关蛋白1(LRP1)胞外域脱落来促进β淀粉样蛋白(Aβ)通过血脑屏障的清除。
Fluids Barriers CNS. 2016 Aug 8;13(1):14. doi: 10.1186/s12987-016-0038-x.
10
Fusion antibody for Alzheimer's disease with bidirectional transport across the blood-brain barrier and abeta fibril disaggregation.用于阿尔茨海默病的融合抗体,具有双向穿越血脑屏障和β淀粉样蛋白原纤维解聚的功能。
Bioconjug Chem. 2007 Mar-Apr;18(2):447-55. doi: 10.1021/bc060349x. Epub 2007 Feb 22.

引用本文的文献

1
Hydrogen Sulfide Attenuates Lipopolysaccharide-Induced Inflammation via the P-glycoprotein and NF-κB Pathway in Astrocytes.硫化氢通过 P-糖蛋白和 NF-κB 通路减轻脂多糖诱导的星形胶质细胞炎症。
Neurochem Res. 2023 May;48(5):1424-1437. doi: 10.1007/s11064-022-03840-5. Epub 2022 Dec 8.
2
Elimination of substances from the brain parenchyma: efflux via perivascular pathways and via the blood-brain barrier.脑实质中物质的消除:通过血管周围途径和血脑屏障的外排。
Fluids Barriers CNS. 2018 Oct 19;15(1):30. doi: 10.1186/s12987-018-0113-6.
3
P-glycoprotein (ABCB1) and Oxidative Stress: Focus on Alzheimer's Disease.
P-糖蛋白(ABCB1)与氧化应激:聚焦阿尔茨海默病。
Oxid Med Cell Longev. 2017;2017:7905486. doi: 10.1155/2017/7905486. Epub 2017 Nov 26.
4
P-glycoprotein Function in the Rodent Brain Displays a Daily Rhythm, a Quantitative In Vivo PET Study.啮齿动物大脑中P-糖蛋白功能呈现每日节律,一项定量体内PET研究
AAPS J. 2016 Nov;18(6):1524-1531. doi: 10.1208/s12248-016-9973-3. Epub 2016 Sep 6.
5
Evaluation of [F]MC225 as a PET radiotracer for measuring P-glycoprotein function at the blood-brain barrier in rats: Kinetics, metabolism, and selectivity.评估[F]MC225作为正电子发射断层显像(PET)放射性示踪剂用于测量大鼠血脑屏障处P-糖蛋白功能:动力学、代谢及选择性
J Cereb Blood Flow Metab. 2017 Apr;37(4):1286-1298. doi: 10.1177/0271678X16654493. Epub 2016 Jan 1.
6
Evidence against a role of P-glycoprotein in the clearance of the Alzheimer's disease Aβ1-42 peptides.关于P-糖蛋白在阿尔茨海默病Aβ1-42肽清除过程中作用的反向证据。
Cell Stress Chaperones. 2015 May;20(3):421-30. doi: 10.1007/s12192-014-0566-8. Epub 2015 Jan 16.
7
1α,25-Dihydroxyvitamin D3 reduces cerebral amyloid-β accumulation and improves cognition in mouse models of Alzheimer's disease.1α,25-二羟维生素 D3 可减少阿尔茨海默病小鼠模型中的脑淀粉样β积累并改善认知。
J Neurosci. 2014 May 21;34(21):7091-101. doi: 10.1523/JNEUROSCI.2711-13.2014.
8
1α,25-Dihydroxyvitamin D3-liganded vitamin D receptor increases expression and transport activity of P-glycoprotein in isolated rat brain capillaries and human and rat brain microvessel endothelial cells.1α,25-二羟维生素 D3 配位的维生素 D 受体增加分离的大鼠脑毛细血管和人及大鼠脑微血管内皮细胞中 P 糖蛋白的表达和转运活性。
J Neurochem. 2012 Dec;123(6):944-53. doi: 10.1111/jnc.12041. Epub 2012 Nov 1.
9
PET and SPECT radiotracers to assess function and expression of ABC transporters in vivo.正电子发射断层扫描和单光子发射计算机断层扫描放射性示踪剂评估 ABC 转运体在体内的功能和表达。
Curr Drug Metab. 2011 Oct;12(8):774-92. doi: 10.2174/138920011798356980.