TCR 亲和力过高可能并不适合疫苗设计的金发姑娘模型。
The Goldilocks model for TCR-too much attraction might not be best for vaccine design.
机构信息
University of Colorado Denver School of Medicine, Denver, Colorado, USA.
出版信息
PLoS Biol. 2010 Sep 14;8(9):e1000482. doi: 10.1371/journal.pbio.1000482.
Abstract
Recent research on T cell-antigen interactions suggests that tighter binding is not always better at eliciting an effective immune response.
摘要
最近关于 T 细胞-抗原相互作用的研究表明，在引发有效的免疫反应方面，更紧密的结合并不总是更好。
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