Department of Psychiatry, University of California San Diego, La Jolla, 92093-0804, USA.
Curr Psychiatry Rep. 2010 Dec;12(6):572-8. doi: 10.1007/s11920-010-0149-z.
Cortical electrophysiologic event-related potentials are multidimensional measures of information processing that are well-suited for efficiently parsing automatic and controlled components of cognition that span the range of deficits evidenced in schizophrenia patients. These information processes are key cognitive measures that are recognized as informative and valid targets for understanding the neurobiology of schizophrenia. These measures may be used in concert with the Measurement and Treatment Research to Improve Cognition in Schizophrenia (MATRICS) neurocognitive measures in the development of novel treatments for schizophrenia and related neuropsychiatric disorders. The employment of novel event-related potential paradigms designed to carefully characterize the early spectrum of perceptual and cognitive information processing allows investigators to identify the neurophysiologic basis of cognitive dysfunction in schizophrenia and to examine the associated clinical and functional impairments.
皮层电生理事件相关电位是多维信息处理测量指标，非常适合有效地分析认知的自动和控制成分，这些成分涵盖了精神分裂症患者表现出的一系列缺陷。这些信息处理过程是关键的认知测量指标，被认为是理解精神分裂症神经生物学的有意义和有效的靶点。这些测量指标可以与“测量和治疗研究以改善精神分裂症认知（MATRICS）”的神经认知测量指标一起，用于开发新型精神分裂症和相关神经精神疾病的治疗方法。采用新的事件相关电位范式来仔细描述早期的感知和认知信息处理范围，可以让研究者确定精神分裂症认知功能障碍的神经生理基础，并检查相关的临床和功能障碍。
