Sueyoshi Kazuki, Sumiyoshi Tomiki
Department of Preventive Intervention for Psychiatric Disorders, National Institute of Mental Health, National Center of Neurology and Psychiatry, Kodaira, Japan.
Front Psychiatry. 2018 Jun 13;9:259. doi: 10.3389/fpsyt.2018.00259. eCollection 2018.
Several domains of cognitive function, e.g., verbal memory, information processing, fluency, attention, and executive function are impaired in patients with schizophrenia. Cognitive impairments in schizophrenia have attracted interests as a treatment target, because they are considered to greatly affect functional outcome. Electrophysiological markers, including electroencephalogram (EEG), particularly, event-related potentials, have contributed to psychiatric research and clinical practice. In this review, we provide a summary of studies relating electrophysiological findings to cognitive performance in schizophrenia. Electrophysiological indices may provide an objective marker of cognitive processes, contributing to the development of effective interventions to improve cognitive and social outcomes. Further efforts to understand biological mechanisms of cognitive disturbances, and develop effective therapeutics are warranted.
精神分裂症患者存在多个认知功能领域受损，例如言语记忆、信息处理、流畅性、注意力和执行功能。精神分裂症中的认知障碍作为一个治疗靶点已引起关注，因为它们被认为会极大地影响功能结局。包括脑电图（EEG）在内的电生理标志物，尤其是事件相关电位，已对精神病学研究和临床实践有所贡献。在本综述中，我们总结了将电生理结果与精神分裂症认知表现相关联的研究。电生理指标可能提供认知过程的客观标志物，有助于开发有效的干预措施以改善认知和社会结局。有必要进一步努力了解认知障碍的生物学机制并开发有效的治疗方法。
