Inagaki S, Matsuda Y, Nakai Y, Takagi H
First Department of Anatomy, Osaka City University Medical School, Japan.
Brain Res. 1990 Dec 24;537(1-2):263-70. doi: 10.1016/0006-8993(90)90367-k.
The posterior caudate-putamen and perirhinal cortex are innervated by fibers immunoreactive to calcitonin gene-related peptide (CGRP). We investigated the origins of these fibers by using immunohistochemistry combined with lesion experiments and fluorescent dye tracers. Lesions of the posterior thalamus surrounding the medial geniculate nucleus, in which groups of CGRP-like immunoreactive (CGRP-LI) cells exist, decreased the number of ipsilaterally CGRP-LI fibers in the posterior caudate-putamen and partly in the perirhinal cortex. Some of CGRP-LI neurons in several posterior thalamic nuclei surrounding the medial geniculate nucleus were labeled with both Fast blue injected into the posterior caudate-putamen and fluoro-gold administered into the anterior perirhinal cortex. Our results indicate that CGRP-LI cells in the posterior thalamus, such as posterior intralaminar, lateral subparafascicular and subparafascicular nuclei, project either separately or simultaneously to innervate the posterior caudate-putamen and perirhinal cortex.
尾状核-壳核后部及嗅周皮质由降钙素基因相关肽（CGRP）免疫反应性纤维支配。我们采用免疫组织化学结合损伤实验及荧光染料示踪剂的方法，研究了这些纤维的起源。在内侧膝状体周围的丘脑后部进行损伤，此处存在成群的CGRP样免疫反应性（CGRP-LI）细胞，损伤减少了同侧尾状核-壳核后部以及部分嗅周皮质中CGRP-LI纤维的数量。向尾状核-壳核后部注射快蓝及向前嗅周皮质注射荧光金后，内侧膝状体周围几个丘脑后核中的一些CGRP-LI神经元被标记。我们的结果表明，丘脑后部的CGRP-LI细胞，如丘脑板内核后部、外侧束旁下核及束旁核，单独或同时投射以支配尾状核-壳核后部及嗅周皮质。
