Kubota Y, Inagaki S, Shimada S, Takatsuji K, Tohyama M, Takagi H
Department of Anatomy, Osaka University Medical School, Japan.
Neuroscience. 1991;40(2):423-8. doi: 10.1016/0306-4522(91)90130-g.
The sources of fibers with immunoreactivity to calcitonin gene-related peptide in the caudal portion of the caudate-putamen were investigated in animals treated by a knife cut, a tracer injection, or an electrolytic lesion of regions ventral and medial to the medial geniculate nucleus. Hemitransection of the brain just caudal to the caudate-putamen decreased ipsilaterally calcitonin gene-related peptide-like immunoreactivity in the caudal portion of the caudate-putamen, suggesting that calcitonin gene-related peptide-like immunoreactive fibers in the caudate-putamen originated from neurons in the area caudal to the caudate-putamen. Some calcitonin gene-related peptide-like immunoreactive neurons in the regions ventral and medial to the medial geniculate nucleus, including the peripeduncular, posterior intralaminar and suprageniculate nuclei, were labeled ipsilaterally with a retrograde tracer after an injection into the caudal portion of the caudate-putamen. In addition, an electrolytic lesion of calcitonin gene-related peptide-like immunoreactive neurons in the regions ventral and medial to the medial geniculate nucleus decreased the number of calcitonin gene-related peptide-like immunoreactive fibers in the ipsilateral caudal portion of the caudate-putamen. These results suggest that some cells containing calcitonin gene-related peptide in several posterior thalamic nuclei project to the caudal caudate-putamen.
在接受了刀切割、示踪剂注射或内侧膝状核腹侧和内侧区域电解损伤的动物中，研究了尾状核-壳核尾部对降钙素基因相关肽具有免疫反应性的纤维来源。在尾状核-壳核尾侧的脑半横断术使尾状核-壳核尾部同侧的降钙素基因相关肽样免疫反应性降低，这表明尾状核-壳核中的降钙素基因相关肽样免疫反应性纤维起源于尾状核-壳核尾侧区域的神经元。在向尾状核-壳核尾部注射后，内侧膝状核腹侧和内侧区域（包括脚周核、后内侧核和上膝核）的一些降钙素基因相关肽样免疫反应性神经元被逆行示踪剂同侧标记。此外，内侧膝状核腹侧和内侧区域的降钙素基因相关肽样免疫反应性神经元的电解损伤减少了同侧尾状核-壳核尾部降钙素基因相关肽样免疫反应性纤维的数量。这些结果表明，几个丘脑后核中一些含有降钙素基因相关肽的细胞投射到尾状核-壳核尾部。
