Edino S T, Mohammed A Z, Ochicha O, Malami S A, Yakubu A A
Department of Surgery, Bayero University Kano.
Niger J Clin Pract. 2010 Sep;13(3):298-300.
Cancer is an occasional incidental finding in nodular goiter, but there has been no formal study on this disease in our locality.
To determine the occurrence of histologically diagnosed malignancy in patients who present with nodular goiters.
This is a 7-year (2000-2006) retrospective study of all histologically diagnosed malignancies within nodular goiters at Aminu Kano Teaching Hospital, Kano.
There were 160 multinodular goiters during the study period, out of which 24 (15.0%) had histologically diagnosed cancer, and 1 out of the thirteen patients with solitary thyroid nodule (7.6%) had carcinoma. The ages of the patients with carcinoma ranged from 16 to 65 years, with a mean age of 38.8 years. Eighteen (72%) were females, and 7 (28%) were males. Six out of the 25 cases of carcinoma were detected preoperatively by fine needle aspiration cytology. Well differentiated follicular carcinoma was the predominant histological type in 13 (52%) cases, followed by papillary in 10 (40%), medullary carcinoma in 1 (4%) and anaplastic carcinoma in 1 (4%) patient.
One-seventh of nodular goiters in our center harboured malignancy, and follicular carcinoma was the prevalent histological type. This is consistent with the findings elsewhere in endemic goitrous regions. Ultrasound guided fine needle aspiration would improve preoperative diagnosis and guide appropriate surgical management.
癌症是结节性甲状腺肿中偶尔出现的意外发现，但在我们当地尚未对这种疾病进行过正式研究。
确定出现结节性甲状腺肿的患者中经组织学诊断为恶性肿瘤的发生率。
这是一项对卡诺阿明努·卡诺教学医院7年（2000 - 2006年）期间所有经组织学诊断为结节性甲状腺肿内恶性肿瘤的回顾性研究。
研究期间有160例多结节性甲状腺肿，其中24例（15.0%）经组织学诊断为癌症，13例孤立性甲状腺结节患者中有1例（7.6%）患有癌。患癌患者年龄在16至65岁之间，平均年龄为38.8岁。18例（72%）为女性，7例（28%）为男性。25例癌中有6例术前通过细针穿刺细胞学检查发现。高分化滤泡癌是13例（52%）病例中的主要组织学类型，其次是乳头状癌10例（40%）、髓样癌1例（4%）和未分化癌1例（4%）。
我们中心七分之一的结节性甲状腺肿含有恶性肿瘤，滤泡癌是主要的组织学类型。这与地方性甲状腺肿地区其他地方的研究结果一致。超声引导下细针穿刺将改善术前诊断并指导适当的手术管理。
