Nozaki-Renard J, Iino T, Sato Y, Marumoto Y, Ohta G, Furusawa M
Department of Microbiology, Tokyo Medical College, Japan.
Cell Struct Funct. 1990 Oct;15(5):295-9. doi: 10.1247/csf.15.295.
Infection of the human lymphocyte CEM cell line with the HIV-1 (human immunodeficiency virus-1, LAV-1 strain) results in cell death. A fluoroquinolone antibiotic, ofloxacin, protected the infected cells from HIV-1-mediated cytolysis. Other fluoroquinolones, e.g. ciprofloxacin, norfloxacin, and enoxacin, also protected the infected cells from HIV-1-mediated cytolysis. The d-isomer of ofloxacin (DR-3354) was about 50-fold less effective than the l-isomer (DR-3355). Almost none of the rescued cells had detectable HIV-antigens and they could be maintained for long periods in vitro without drugs.
