丁香（Syzygium aromaticum）芽中的抑制成分对 B16 黑色素瘤细胞中黑色素的形成。
Inhibitory components from the buds of clove (Syzygium aromaticum) on melanin formation in B16 melanoma cells.
机构信息
Department of Agro-environmental Sciences, Faculty of Agriculture, Kyushu University, Fukuoka 812-8581, Japan.
出版信息
Fitoterapia. 2011 Mar;82(2):198-202. doi: 10.1016/j.fitote.2010.09.008. Epub 2010 Sep 19.
In the course to find a new whitening agent, we evaluated the methanol extract from bud of clove (Syzygium aromaticum) on melanin formation in B16 melanoma cells. Eugenol and eugenol acetate were isolated as the active compounds and showed melanin inhibition of 60% and 40% in B16 melanoma cell with less cytotoxicity at the concentration of 100 and 200 μg/mL, respectively. Furthermore, an essential oil prepared from the bud of clove, which contain eugenol and eugenol acetate as dominant components, showed melanin inhibition of 50% and 80% in B16 melanoma cells at the concentration of 100 and 200 μg/mL, respectively.
在寻找新型美白剂的过程中，我们评估了丁香花蕾（丁香）甲醇提取物对 B16 黑色素瘤细胞中黑色素形成的影响。丁香酚和乙酸丁香酚被分离为活性化合物，在浓度为 100 和 200μg/mL 时，对 B16 黑色素瘤细胞的黑色素抑制率分别为 60%和 40%，且细胞毒性较低。此外，由丁香花蕾制备的精油，其中丁香酚和乙酸丁香酚为主要成分，在浓度为 100 和 200μg/mL 时，对 B16 黑色素瘤细胞的黑色素抑制率分别为 50%和 80%。
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