一种噻吩-硫代氧杂罗丹明偶联物荧光探针，用于检测水相介质和活细胞中的汞。
A thiophen-thiooxorhodamine conjugate fluorescent probe for detecting mercury in aqueous media and living cells.
机构信息
College of Science and State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing University of Technology, Nanjing 210009, P. R. China.
出版信息
Org Biomol Chem. 2010 Nov 7;8(21):4819-22. doi: 10.1039/c0ob00452a. Epub 2010 Sep 22.
A rhodamine-based sensor RB-S2 was designed and synthesized by combination of the thiospirolacton chromophore and the thiophen ring block with high affinity to Hg(2+). Probe RB-S2 exhibits high selectivity and excellent sensitivity in both absorbance and fluorescence detection of Hg(2+) in aqueous solution. In addition, fluorescent imaging of Hg(2+) in MCF-7 cells is also successfully demonstrated.
设计并合成了一种基于罗丹明的传感器 RB-S2，它由硫代螺内酯生色团和噻吩环组成，对 Hg(2+) 具有高亲和力。探针 RB-S2 在水溶液中对 Hg(2+) 的吸收和荧光检测均表现出高选择性和高灵敏度。此外，还成功地实现了 MCF-7 细胞中 Hg(2+) 的荧光成像。
Zotero 插件