Institute for Cellular Therapeutics, University of Louisville, 570 S. Preston Street, Suite 404, Louisville, KY 40202-1760, USA.
Stem Cell Rev Rep. 2011 Jun;7(2):434-45. doi: 10.1007/s12015-010-9192-8.
Retinal degenerative diseases that target photoreceptors or the adjacent retinal pigment epithelium (RPE) affect millions of people worldwide. Retinal degeneration (RD) is found in many different forms of retinal diseases including retinitis pigmentosa (RP), age-related macular degeneration (AMD), diabetic retinopathy, cataracts, and glaucoma. Effective treatment for retinal degeneration has been widely investigated. Gene-replacement therapy has been shown to improve visual function in inherited retinal disease. However, this treatment was less effective with advanced disease. Stem cell-based therapy is being pursued as a potential alternative approach in the treatment of retinal degenerative diseases. In this review, we will focus on stem cell-based therapies in the pipeline and summarize progress in treatment of retinal degenerative disease.
针对光感受器或相邻视网膜色素上皮 (RPE) 的视网膜退行性疾病影响着全球数百万人。视网膜变性 (RD) 存在于许多不同形式的视网膜疾病中，包括色素性视网膜炎 (RP)、年龄相关性黄斑变性 (AMD)、糖尿病性视网膜病变、白内障和青光眼。人们广泛研究了有效的视网膜变性治疗方法。基因替代疗法已被证明可改善遗传性视网膜疾病的视觉功能。然而，对于晚期疾病，这种治疗效果较差。基于干细胞的治疗方法正被作为治疗视网膜退行性疾病的潜在替代方法进行研究。在这篇综述中，我们将重点关注正在研发中的基于干细胞的治疗方法，并总结治疗视网膜退行性疾病的进展。
