新发现的 KI、WU 和 Merkel 细胞多瘤病毒：无母婴传播证据。
Newly discovered KI, WU, and Merkel cell polyomaviruses: no evidence of mother-to-fetus transmission.
机构信息
Department of Virology, Haartman Institute, University of Helsinki, Helsinki, Finland.
出版信息
Virol J. 2010 Sep 22;7:251. doi: 10.1186/1743-422X-7-251.
BACKGROUND
Three* human polyomaviruses have been discovered recently, KIPyV, WUPyV and MCPyV. These viruses appear to circulate ubiquitously; however, their clinical significance beyond Merkel cell carcinoma is almost completely unknown. In particular, nothing is known about their preponderance in vertical transmission. The aim of this study was to investigate the frequency of fetal infections by these viruses. We sought the three by PCR, and MCPyV also by real-time quantitative PCR (qPCR), from 535 fetal autopsy samples (heart, liver, placenta) from intrauterine fetal deaths (IUFDs) (N = 169), miscarriages (120) or induced abortions (246). We also measured the MCPyV IgG antibodies in the corresponding maternal sera (N = 462) mostly from the first trimester.
RESULTS
No sample showed KIPyV or WUPyV DNA. Interestingly, one placenta was reproducibly PCR positive for MCPyV. Among the 462 corresponding pregnant women, 212 (45.9%) were MCPyV IgG seropositive.
CONCLUSIONS
Our data suggest that none of the three emerging polyomaviruses often cause miscarriages or IUFDs, nor are they transmitted to fetuses. Yet, more than half the expectant mothers were susceptible to infection by the MCPyV.
背景
最近发现了三种人类多瘤病毒，即 KIPyV、WUPyV 和 MCPyV。这些病毒似乎广泛传播；然而，除了 Merkel 细胞癌之外，它们的临床意义几乎完全未知。特别是，它们在垂直传播中的优势还一无所知。本研究的目的是调查这些病毒导致胎儿感染的频率。我们通过 PCR 检测了这三种病毒，通过实时定量 PCR（qPCR）检测了 MCPyV，共检测了来自宫内胎儿死亡（IUFD）（n = 169）、流产（n = 120）或人工流产（n = 246）的 535 例胎儿尸检样本（心脏、肝脏、胎盘）。我们还测量了相应的母体血清（n = 462）中的 MCPyV IgG 抗体，这些血清大多来自孕早期。
结果
没有样本显示 KIPyV 或 WUPyV DNA。有趣的是，一个胎盘的 MCPyV 经 PCR 重复检测呈阳性。在 462 名相应的孕妇中，212 名（45.9%）MCPyV IgG 血清阳性。
结论
我们的数据表明，这三种新兴的多瘤病毒都不会经常导致流产或 IUFD，也不会传播给胎儿。然而，超过一半的孕妇易感染 MCPyV。
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