Department of Surgical Oncology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
J Clin Pathol. 2010 Dec;63(12):1054-8. doi: 10.1136/jcp.2010.078600. Epub 2010 Sep 21.
Angiopoietin-like protein 4 (ANGPTL4) is involved in regulating glucose homeostasis, insulin sensitivity, angiogenesis and lipid metabolism, and also acts as an apoptosis survival factor for vascular endothelial cells. The protein is also known to be induced in hypoxic environments characteristic of cancer tissue. Recently, ANGPTL4 was shown in cancer cells to facilitate the transendothelial passage of the cells, resulting in distant metastasis. Clinically, venous invasion resulting in distant metastasis is crucial for oesophageal cancer progression.
To determine ANGPTL4 expression and its association with clinicopathological factors and prognosis in human oesophageal squamous cell carcinoma (OSCC).
104 cases of surgically-resected OSCC specimens were examined by immunohistochemistry. The association of ANGPTL4 expression with clinicopathological characteristics and postoperative survival rate was statistically analysed.
Expression of ANGPTL4 was statistically correlated with the degree of differentiation, lymphatic invasion and venous invasion. Results of multivariate analysis, performed using multiple logistic regression, showed that lymph node metastasis, lymphatic invasion and ANGPTL4 expression were independent factors predicting venous invasion. Survival rates of patients with ANGPTL4-positive tumours tended to be statistically lower than those with ANGPTL4-negative tumours.
ANGPTL4 may play an important role in metastasis through lymphovascular invasion, and may potentially affect prognosis.
血管生成素样蛋白 4（ANGPTL4）参与调节葡萄糖稳态、胰岛素敏感性、血管生成和脂代谢，并且作为血管内皮细胞的凋亡生存因子发挥作用。该蛋白也已知在肿瘤组织中特征性的缺氧环境中被诱导。最近，ANGPTL4 被证明在癌细胞中促进细胞的跨内皮迁移，导致远处转移。临床上，导致远处转移的静脉侵犯对食管癌的进展至关重要。
确定血管生成素样蛋白 4（ANGPTL4）在人食管鳞状细胞癌（OSCC）中的表达及其与临床病理因素和预后的关系。
通过免疫组织化学检测 104 例手术切除的 OSCC 标本。统计分析 ANGPTL4 表达与临床病理特征和术后生存率的关系。
ANGPTL4 的表达与分化程度、淋巴浸润和静脉浸润有统计学相关性。多因素分析（使用多元逻辑回归）的结果显示，淋巴结转移、淋巴浸润和 ANGPTL4 表达是预测静脉侵犯的独立因素。ANGPTL4 阳性肿瘤患者的生存率趋于低于 ANGPTL4 阴性肿瘤患者。
ANGPTL4 可能通过淋巴血管侵犯在转移中发挥重要作用，并可能影响预后。
