Zhang Xinling, Liu Dongang, Qiu Yuting, Hu Ruiyao, Chen Shiyu, Xu Yue, Qian Chenyan, Du Lailing, Yuan Jinghua, Li Xiaoping
Key Laboratory of Artificial Organs and Computational Medicine in Zhejiang Province, Shulan International Medical College, Zhejiang Shuren University, Hangzhou 310015, China.
Metabolites. 2025 May 26;15(6):352. doi: 10.3390/metabo15060352.
Angiopoietin-like proteins (ANGPTLs) represent a family of secreted glycoproteins that are extensively expressed in vivo and are integral to various pathophysiological processes, including glucose and lipid metabolism, stem cell proliferation, local inflammation, vascular permeability, and angiogenesis. Particularly interesting is ANGPTL4, which has been identified as a significant factor in the development and progression of diabetic retinopathy (DR), thus becoming a central focus of DR research. ANGPTLs modulate metabolic pathways, enhance vascular permeability, and facilitate pathological angiogenesis, in addition to causing intraocular inflammation. As promising molecular targets, ANGPTLs not only serve as biomarkers for predicting the onset and progression of DR but also present therapeutic potential through antibody-based interventions. This paper discusses the pathogenesis of DR and the potential applications of ANGPTLs in early diagnosis and targeted therapy. It provides references for advancing precision diagnosis and personalized treatment strategies through more profound ANGPTLs research in the future.
血管生成素样蛋白（ANGPTLs）是一类分泌型糖蛋白家族，在体内广泛表达，并且是各种病理生理过程不可或缺的一部分，这些过程包括葡萄糖和脂质代谢、干细胞增殖、局部炎症、血管通透性以及血管生成。特别值得关注的是ANGPTL4，它已被确定为糖尿病视网膜病变（DR）发生和发展的一个重要因素，因此成为DR研究的核心焦点。ANGPTLs除了引发眼内炎症外，还能调节代谢途径、增强血管通透性并促进病理性血管生成。作为有前景的分子靶点，ANGPTLs不仅可作为预测DR发病和进展的生物标志物，还通过基于抗体的干预措施展现出治疗潜力。本文讨论了DR的发病机制以及ANGPTLs在早期诊断和靶向治疗中的潜在应用。它为未来通过更深入的ANGPTLs研究推进精准诊断和个性化治疗策略提供了参考。
